BACKGROUND: Helicobacter pylori infection has been linked with chronic atrophic gastritis and gastric cancer. This case-control study was performed to investigate a possible relationship between H. pylori infection and gastric cancer in young age groups. METHODS: Gastrectomy and/or biopsy samples were collected from 50 consecutive patients 45 years old or younger treated between 1980 and 1994 for noncardiac gastric cancer. The control group consisted of age- and sex-matched dyspeptic patients. The presence of H. pylori infection was assessed by modified Giemsa staining and immunostaining, using antibody against H. pylori. RESULTS: H. pylori was found in 36 (72%; 95% confidence interval 60-84%) cancer patients and in 22 (43%; 30-58%) control patients (p = 0.0023, chi-square test). The odds ratio was 3.27 (1.42-7.52). Nonatrophic (superficial) gastritis was present in 30 (60%) cancer patients and in 19 (38%) (p = 0.028, chi-square test) control cases. CONCLUSIONS: The results of the present study support the hypothesis that H. pylori is a risk factor for gastric cancer also in young age groups and in patients with a diffuse type of gastric cancer.
BACKGROUND:Helicobacter pyloriinfection has been linked with chronic atrophic gastritis and gastric cancer. This case-control study was performed to investigate a possible relationship between H. pyloriinfection and gastric cancer in young age groups. METHODS: Gastrectomy and/or biopsy samples were collected from 50 consecutive patients 45 years old or younger treated between 1980 and 1994 for noncardiac gastric cancer. The control group consisted of age- and sex-matched dyspeptic patients. The presence of H. pyloriinfection was assessed by modified Giemsa staining and immunostaining, using antibody against H. pylori. RESULTS:H. pylori was found in 36 (72%; 95% confidence interval 60-84%) cancerpatients and in 22 (43%; 30-58%) control patients (p = 0.0023, chi-square test). The odds ratio was 3.27 (1.42-7.52). Nonatrophic (superficial) gastritis was present in 30 (60%) cancerpatients and in 19 (38%) (p = 0.028, chi-square test) control cases. CONCLUSIONS: The results of the present study support the hypothesis that H. pylori is a risk factor for gastric cancer also in young age groups and in patients with a diffuse type of gastric cancer.
Authors: Eric A Engels; Sholom Wacholder; Hormuzd A Katki; Anil K Chaturvedi Journal: Cancer Epidemiol Biomarkers Prev Date: 2014-07-25 Impact factor: 4.254
Authors: H Tabata; T Fuchigami; H Kobayashi; Y Sakai; M Nakanishi; K Tomioka; S Nakamura; M Fujishima Journal: Dig Dis Sci Date: 1999-10 Impact factor: 3.199