Possible selective elimination of red blood cells under the influence of colloidal silica.

The physical interaction between the red blood cells and colloidal silica leads to hemolysis. We propose that the nature of the red-cell elimination as the result of this interaction is not random. As the negatively charged silica particles at the physiological conditions electrostatically react with the positive sites of the outer side of the cell membrane, it seems reasonable to suppose that the cells with a low density of negative charges on the membrane surface area are more probable to be lysed in the first place.