Literature DB >> 8817649

Antileishmanial effect of a potent S-adenosylmethionine decarboxylase inhibitor: CGP 40215A.

R Mukhopadhyay1, P Kapoor, R Madhubala.   

Abstract

CGP 40215A, specific S-adenosylmethionine decarboxylase (AdoMetDC) inhibitor was found to inhibit the growth of Leishmania donovani promastigotes (strain UR6) in a dose-dependent manner with an IC50 of 18 microM. The growth inhibition was reversed with 100 microM of spermidine and spermine. The growth inhibition in vitro by this inhibitor was accompanied by a significant decrease in AdoMetDC activity and spermidine levels. CGP 40215A was more potent than other AdoMetDC inhibitors, Berenil or methyl glyoxal (bis) guanyl hydrazone. The combination of CGP 40215A with other polyamine biosynthetic inhibitors like DL-alpha-difluoromethylornithine or the bis (benzyl) polyamine analogue (MDL 27695) shows an accentuated inhibitory effect on leishmanial growth.

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Year:  1996        PMID： 8817649     DOI： 10.1006/phrs.1996.0011

Source DB:  PubMed          Journal:  Pharmacol Res        ISSN： 1043-6618            Impact factor:   7.658


  6 in total

1.  Tetraazamacrocyclic derivatives and their metal complexes as antileishmanial leads.

Authors:  Timothy J Hubin; Ashlie N Walker; Dustin J Davilla; TaRynn N Carder Freeman; Brittany M Epley; Travis R Hasley; Prince N A Amoyaw; Surendra Jain; Stephen J Archibald; Timothy J Prior; Jeanette A Krause; Allen G Oliver; Babu L Tekwani; M Omar F Khan
Journal:  Polyhedron       Date:  2019-02-23       Impact factor: 3.052

2.  3-Aminooxy-1-aminopropane and derivatives have an antiproliferative effect on cultured Plasmodium falciparum by decreasing intracellular polyamine concentrations.

Authors:  Robin Das Gupta; Tanja Krause-Ihle; Bärbel Bergmann; Ingrid B Müller; Alex R Khomutov; Sylke Müller; Rolf D Walter; Kai Lüersen
Journal:  Antimicrob Agents Chemother       Date:  2005-07       Impact factor: 5.191

Review 3.  Polyamine Metabolism in Leishmania Parasites: A Promising Therapeutic Target.

Authors:  Nicola S Carter; Yumena Kawasaki; Surbhi S Nahata; Samira Elikaee; Sara Rajab; Leena Salam; Mohammed Y Alabdulal; Kelli K Broessel; Forogh Foroghi; Alyaa Abbas; Reyhaneh Poormohamadian; Sigrid C Roberts
Journal:  Med Sci (Basel)       Date:  2022-04-22

Review 4.  Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities.

Authors:  Lyn-Marie Birkholtz; Marni Williams; Jandeli Niemand; Abraham I Louw; Lo Persson; Olle Heby
Journal:  Biochem J       Date:  2011-09-01       Impact factor: 3.857

5.  Genome-scale reconstruction of the metabolic network in Staphylococcus aureus N315: an initial draft to the two-dimensional annotation.

Authors:  Scott A Becker; Bernhard Ø Palsson
Journal:  BMC Microbiol       Date:  2005-03-07       Impact factor: 3.605

6.  Robenidine Analogues Are Potent Antimalarials in Drug-Resistant Plasmodium falciparum.

Authors:  Alina Krollenbrock; Yuexin Li; Jane Xu Kelly; Michael K Riscoe
Journal:  ACS Infect Dis       Date:  2021-03-16       Impact factor: 5.084
  6 in total

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