[Flow-cytometric study of aneuploidy and proliferative activity of endometrial cancer cells as indicators of tumor aggressiveness].

DNA level and proliferative activity of malignant cells (89), atypical (7), glandular and glandular-cystous hyperplasia (15) of the endometrium and normal endometrium (28) have been assayed by flow cytometry. The results were evaluated versus degree of cell differentiation, depth of invasion and expected clinical prognosis. A reverse relationship was established between aneuplody frequency on the one hand, and cell differentiation degree and poor prognosis, on the other. However, a direct correlation was observed between DNA index and tumor aggressiveness. It was demonstrated that proliferative processes are much more active in non-differentiated cell carcinoma of the endometrium.