Phantom limb pain and etiology of amputation in unilateral lower extremity amputees.

The relationships between phantom limb pain and both the etiology of amputation (blood clots, nonclot diabetes, and miscellaneous) and the occurrence of gangrene and/or infection were investigated in 92 unilateral lower extremity (LE) amputees who were seen sequentially. There were 55 above-knee (AK) and 37 below-knee (BK) amputations in 61 men and 31 women. The mean age was 51.4 years. The blood-clot etiology had the highest levels of phantom pain both pre- and postrehabilitation, the longest time interval between amputation and prosthetic fitting, and the greatest number of medical conditions. The nonclot diabetes and miscellaneous etiologies followed in order. A history of gangrene and/or infection was associated with higher levels of pain and longer time interval between amputation and prosthetic fitting.