Literature DB >> 8814292

Molecular cloning, functional expression and chromosomal localization of a human homolog of the cyclic nucleotide-gated ion channel of retinal cone photoreceptors.

W P Yu1, M E Grunwald, K W Yau.   

Abstract

We have cloned from human retina a cyclic nucleotide-gated (CNG) ion channel that is distinct from the one found in rod photoreceptors. This channel protein is highly homologous to the CNG channel that recently has been cloned from bovine testis and kidney and has been shown to be present in retinal cone photoreceptors. When expressed in human embryonic kidney cells, the protein forms functional ion channels with properties broadly similar to those described for the cloned bovine channel. The gene for this channel resides on chromosome 2.

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Year:  1996        PMID： 8814292     DOI： 10.1016/0014-5793(96)00889-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  24 in total

1.  Ligand sensitivity of the 2 subunit from the bovine cone cGMP-gated channel is modulated by protein kinase C but not by calmodulin.

Authors:  F Müller; M Vantler; D Weitz; E Eismann; M Zoche; K W Koch; U B Kaupp
Journal:  J Physiol       Date:  2001-04-15       Impact factor: 5.182

2.  A cGMP-signaling pathway in a subset of olfactory sensory neurons.

Authors:  M R Meyer; A Angele; E Kremmer; U B Kaupp; F Muller
Journal:  Proc Natl Acad Sci U S A       Date:  2000-09-12       Impact factor: 11.205

3.  Impaired cone function and cone degeneration resulting from CNGB3 deficiency: down-regulation of CNGA3 biosynthesis as a potential mechanism.

Authors:  Xi-Qin Ding; Cynthia S Harry; Yumiko Umino; Alexander V Matveev; Steven J Fliesler; Robert B Barlow
Journal:  Hum Mol Genet       Date:  2009-09-17       Impact factor: 6.150

4.  Developmental expression pattern of phototransduction components in mammalian pineal implies a light-sensing function.

Authors:  S Blackshaw; S H Snyder
Journal:  J Neurosci       Date:  1997-11-01       Impact factor: 6.167

5.  Mutating three residues in the bovine rod cyclic nucleotide-activated channel can switch a nucleotide from inactive to active.

Authors:  S P Scott; J Cummings; J C Joe; J C Tanaka
Journal:  Biophys J       Date:  2000-05       Impact factor: 4.033

6.  Alternative splicing governs cone cyclic nucleotide-gated (CNG) channel sensitivity to regulation by phosphoinositides.

Authors:  Gucan Dai; Tshering Sherpa; Michael D Varnum
Journal:  J Biol Chem       Date:  2014-03-27       Impact factor: 5.157

7.  Molecular determinants of the modulation of cyclic nucleotide-activated channels by calmodulin.

Authors:  M E Grunwald; H Zhong; J Lai; K W Yau
Journal:  Proc Natl Acad Sci U S A       Date:  1999-11-09       Impact factor: 11.205

8.  Molecular cloning and functional characterization of a new modulatory cyclic nucleotide-gated channel subunit from mouse retina.

Authors:  A Gerstner; X Zong; F Hofmann; M Biel
Journal:  J Neurosci       Date:  2000-02-15       Impact factor: 6.167

9.  Functional co-assembly among subunits of cyclic-nucleotide-activated, nonselective cation channels, and across species from nematode to human.

Authors:  J T Finn; D Krautwurst; J E Schroeder; T Y Chen; R R Reed; K W Yau
Journal:  Biophys J       Date:  1998-03       Impact factor: 4.033

10.  Native cone photoreceptor cyclic nucleotide-gated channel is a heterotetrameric complex comprising both CNGA3 and CNGB3: a study using the cone-dominant retina of Nrl-/- mice.

Authors:  Alexander V Matveev; Alexander B Quiambao; J Browning Fitzgerald; Xi-Qin Ding
Journal:  J Neurochem       Date:  2008-07-04       Impact factor: 5.372
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