The effects of cisapride on elemental content in neonatal mouse small intestine in vivo.

The effects of cisapride on elemental content of enterocytes, smooth muscle cells and lamina propria in neonatal mouse jejunum were studied using electron probe X-ray microanalysis. One hour after injection with cisapride (1.7 or 0.017 mg/kg body weight i.p.), Cl content was significantly reduced in villus base, crypt and smooth muscle cells and Na content decreased in muscle cells. No changes were observed in Na or Cl within villus tip cells. Total Ca content did not change significantly in any cell type following treatment with cisapride. These results confirm that cisapride induces net Cl- secretion in neonatal mouse jejunum.