Literature DB >> 8812466

Assignment of human elongation factor 1alpha genes: EEF1A maps to chromosome 6q14 and EEF1A2 to 20q13.3.

A Lund1, S M Knudsen, H Vissing, B Clark, N Tommerup.   

Abstract

The human elongation factor 1alpha gene family consists of at least 2 actively transcribed genes, EEF1A and EEF1A2, and more than 18 homologous loci. EEF1A2 is expressed in a tissue-specific manner, whereas EEF1A is expressed ubiquitously, and both of them can function in translation. An EEF1A cDNA probe has previously been shown to cross-hybridize with several human chromosomes, but the location of the functional gene has not been established. We have mapped the functional EEF1A gene to 6q14 by combined fluorescence in situ hybridization (FISH) and PCR analysis of a somatic cell hybrid panel and mapped EEF1A2 to 20q13.3 by FISH. In addition, the 11 strongest cross-hybridizing loci (EEF1AL2-EEF1AL13) were mapped by FISH to 12p12, 9q34, 7p15-p21, 19q13, 3q26-q27, 7q33-q35, 1p13-p22, 2q12-q14, 5p12-q11, 1q31-q32, and Xq21.

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Year:  1996        PMID： 8812466     DOI： 10.1006/geno.1996.0475

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  31 in total

Review 1.  Not just for housekeeping: protein initiation and elongation factors in cell growth and tumorigenesis.

Authors:  Sarah Thornton; Nisha Anand; Dan Purcell; Jonathan Lee
Journal:  J Mol Med (Berl)       Date:  2003-08-01       Impact factor: 4.599

2.  Genomic shotgun array: a procedure linking large-scale DNA sequencing with regional transcript mapping.

Authors:  Ling-Hui Li; Jian-Chiuan Li; Yung-Feng Lin; Chung-Yen Lin; Chung-Yung Chen; Shih-Feng Tsai
Journal:  Nucleic Acids Res       Date:  2004-02-11       Impact factor: 16.971

3.  Generation of plasmid vectors expressing FLAG-tagged proteins under the regulation of human elongation factor-1α promoter using Gibson assembly.

Authors:  Petar N Grozdanov; Clinton C MacDonald
Journal:  J Vis Exp       Date:  2015-02-09       Impact factor: 1.355

4.  Homozygous EEF1A2 mutation causes dilated cardiomyopathy, failure to thrive, global developmental delay, epilepsy and early death.

Authors:  Siqi Cao; Laura L Smith; Sergio R Padilla-Lopez; Brandon S Guida; Elizabeth Blume; Jiahai Shi; Sarah U Morton; Catherine A Brownstein; Alan H Beggs; Michael C Kruer; Pankaj B Agrawal
Journal:  Hum Mol Genet       Date:  2017-09-15       Impact factor: 6.150

5.  The eEFIA gene family is differentially expressed in maize endosperm.

Authors:  N P Carneiro; P A Hughes; B A Larkins
Journal:  Plant Mol Biol       Date:  1999-12       Impact factor: 4.076

6.  Porcine EEF1A1 and EEF1A2 genes: genomic structure, polymorphism, mapping and expression.

Authors:  Kateřina Svobodová; Pavel Horák; Antonín Stratil; Heinz Bartenschlager; Mario Van Poucke; Pavla Chalupová; Věra Dvořáková; Christoph Knorr; Roman Stupka; Jaroslav Čítek; Michal Šprysl; Anna Palánová; Luc J Peelman; Hermann Geldermann; Aleš Knoll
Journal:  Mol Biol Rep       Date:  2015-03-08       Impact factor: 2.316

7.  Tumor suppressor p16(INK4a) inhibits cancer cell growth by downregulating eEF1A2 through a direct interaction.

Authors:  Mee-Hyun Lee; Bu Young Choi; Yong-Yeon Cho; Sung-Young Lee; Zunnan Huang; Joydeb Kumar Kundu; Myoung Ok Kim; Dong Joon Kim; Ann M Bode; Young-Joon Surh; Zigang Dong
Journal:  J Cell Sci       Date:  2013-02-26       Impact factor: 5.285

8.  Eukaryotic elongation factor 1A2 cooperates with phosphatidylinositol-4 kinase III beta to stimulate production of filopodia through increased phosphatidylinositol-4,5 bisphosphate generation.

Authors:  Sujeeve Jeganathan; Anne Morrow; Anahita Amiri; Jonathan M Lee
Journal:  Mol Cell Biol       Date:  2008-05-12       Impact factor: 4.272

9.  The interaction between interferon-induced protein with tetratricopeptide repeats-1 and eukaryotic elongation factor-1A.

Authors:  Hong-Tao Li; Yong-Ping Su; Tian-Min Cheng; Jian-Ming Xu; Jie Liao; Ji-Chuan Chen; Chang-You Ji; Guo-Ping Ai; Jun-Ping Wang
Journal:  Mol Cell Biochem       Date:  2009-10-24       Impact factor: 3.396

10.  Structural insights into the interaction of the evolutionarily conserved ZPR1 domain tandem with eukaryotic EF1A, receptors, and SMN complexes.

Authors:  Ashwini K Mishra; Laxman Gangwani; Roger J Davis; David G Lambright
Journal:  Proc Natl Acad Sci U S A       Date:  2007-08-17       Impact factor: 11.205
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