| Literature DB >> 8809858 |
N D Volkow1, J S Fowler, Y S Ding.
Abstract
This study documented marked accumulation of cocaine in the human and baboon heart, which was not inhibited by desipramine pretreatment. However, cocaine inhibited 6-[18F]fluoronorepinephrine uptake in heart to the same degree as did desipramine (Fowler et al. 1994). Since uptake of [18F]norepinephrine in the heart is a function of its uptake by the NE transporter (Fowler et al. 1994), its inhibition by cocaine corroborates in vivo a significant interaction of cocaine with this transporter.Entities:
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Year: 1996 PMID： 8809858
Source DB: PubMed Journal: NIDA Res Monogr ISSN： 1046-9516