Literature DB >> 8809118

Fatty acids selectively inhibit eukaryotic DNA polymerase activities in vitro.

Y Mizushina1, N Tanaka, H Yagi, T Kurosawa, M Onoue, H Seto, T Horie, N Aoyagi, M Yamaoka, A Matsukage, S Yoshida, K Sakaguchi.   

Abstract

The in vitro relationship between eukaryotic DNA polymerases and fatty acids was investigated. Some fatty acids strongly inhibited the activities of DNA polymerase alpha and/or beta in vitro. The kinetics of inhibition by linoleic acid showed that DNA polymerase alpha was non-competitively inhibited with respect to the DNA template and substrate (dTTP), while DNA polymerase beta was inhibited competitively with both DNA and substrate.

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Year:  1996        PMID： 8809118     DOI： 10.1016/0167-4781(96)00121-2

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  27 in total

1.  Inhibitory action of conjugated C18-fatty acids on DNA polymerases and DNA topoisomerases.

Authors:  Yoshiyuki Mizushina; Tsuyoshi Tsuzuki; Takahiro Eitsuka; Teruo Miyazawa; Kanako Kobayashi; Hiroshi Ikawa; Isoko Kuriyama; Yuko Yonezawa; Masaharu Takemura; Hiromi Yoshida; Kengo Sakaguchi
Journal:  Lipids       Date:  2004-10       Impact factor: 1.880

2.  Three acetophenones from Acronychia pedunculata.

Authors:  Sachiko Kozaki; Yukiko Takenaka; Yoshiyuki Mizushina; Takao Yamaura; Takao Tanahashi
Journal:  J Nat Med       Date:  2013-10-16       Impact factor: 2.343

Review 3.  Metabolism and functions of highly unsaturated fatty acids: an update.

Authors:  M T Nakamura; H P Cho; J Xu; Z Tang; S D Clarke
Journal:  Lipids       Date:  2001-09       Impact factor: 1.880

4.  A sulphoquinovosyl diacylglycerol is a DNA polymerase epsilon inhibitor.

Authors:  Yoshiyuki Mizushina; Xianai Xu; Hitomi Asahara; Ryo Takeuchi; Masahiko Oshige; Noriko Shimazaki; Masaharu Takemura; Toyofumi Yamaguchi; Kazufumi Kuroda; Stuart Linn; Hiromi Yoshida; Osamu Koiwai; Mineo Saneyoshi; Fumio Sugawara; Kengo Sakaguchi
Journal:  Biochem J       Date:  2003-02-15       Impact factor: 3.857

5.  Novel triterpenoids inhibit both DNA polymerase and DNA topoisomerase.

Authors:  Y Mizushina; A Iida; K Ohta; F Sugawara; K Sakaguchi
Journal:  Biochem J       Date:  2000-09-15       Impact factor: 3.857

6.  Inhibition of telomerase by linear-chain fatty acids: a structural analysis.

Authors:  Masako Oda; Takamasa Ueno; Nobuyuki Kasai; Hirotada Takahashi; Hiromi Yoshida; Fumio Sugawara; Kengo Sakaguchi; Hideya Hayashi; Yoshiyuki Mizushina
Journal:  Biochem J       Date:  2002-10-15       Impact factor: 3.857

7.  Exploration of antiplasmodial activity in Acalypha wilkesiana Müller Argoviensis, 1866 (family: Euphorbiaceae) and its GC-MS fingerprint.

Authors:  Wandayi Emmanuel Amlabu; Ishaya Haruna Nock; Naveen Kumar Kaushik; Dinesh Mohanakrishnan; Jyoti Tiwary; Patrick Ahmadu Audu; Musbahu S Abubakar; Dinkar Sahal
Journal:  Parasitol Res       Date:  2018-03-17       Impact factor: 2.289

8.  Inhibitory action of emulsified sulfoquinovosyl acylglycerol on mammalian DNA polymerases.

Authors:  Yoshiyuki Mizushina; Naoki Maeda; Miho Kawasaki; Hideki Ichikawa; Chikako Murakami; Masaharu Takemura; Xianai Xu; Fumio Sugawara; Yoshinobu Fukumori; Hiromi Yoshida; Kengo Sakaguchi
Journal:  Lipids       Date:  2003-10       Impact factor: 1.880

9.  Inhibitory effects of cholesterol derivatives on DNA polymerase and topoisomerase activities, and human cancer cell growth.

Authors:  Chisato Ishimaru; Yuko Yonezawa; Isoko Kuriyama; Masayuki Nishida; Hiromi Yoshida; Yoshiyuki Mizushina
Journal:  Lipids       Date:  2008-01-24       Impact factor: 1.880

10.  3-O-methylfunicone, a selective inhibitor of mammalian Y-family DNA polymerases from an Australian sea salt fungal strain.

Authors:  Yoshiyuki Mizushina; Hirohisa Motoshima; Yasuhiro Yamaguchi; Toshifumi Takeuchi; Ken Hirano; Fumio Sugawara; Hiromi Yoshida
Journal:  Mar Drugs       Date:  2009-11-23       Impact factor: 5.118
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