Literature DB >> 8808782

Indomethacin loaded chitosan microspheres. Correlation between the erosion process and release kinetics.

I Orienti, K Aiedeh, E Gianasi, V Bertasi, V Zecchi.   

Abstract

The preparation of chitosan microspheres covalently linked with citric acid and loaded with indomethacin is described. The release kinetics correlated with the concentration of chitosan in the microsphere preparative mixture and the pH of the release medium. Deviations from Fickian to zero order kinetics were observed at higher concentrations of chitosan and at pH 7.4. The variations induced by these parameters on drug diffusion and solubility in the matrix undergoing erosion were analyzed.

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Year:  1996        PMID： 8808782     DOI： 10.3109/02652049609026031

Source DB:  PubMed          Journal:  J Microencapsul        ISSN： 0265-2048            Impact factor:   3.142


  10 in total

1.  Evaluation of mucoadhesive properties of chitosan microspheres prepared by different methods.

Authors:  Sanju Dhawan; Anil Kumar Singla; Vivek Ranjan Sinha
Journal:  AAPS PharmSciTech       Date:  2004-07-26       Impact factor: 3.246

2.  Synthesis and Characterization of Porous Chitosan/Saccharomycetes Adsorption Microspheres.

Authors:  Wei Song; Qingzhu Zhang; Yuxin Guan; Wanyan Li; Siyu Xie; Jin Tong; Mo Li; Lili Ren
Journal:  Polymers (Basel)       Date:  2022-06-05       Impact factor: 4.967

3.  Ionic Cross-linked Chitosan Beads for Extended Release of Ciprofloxacin: In vitro Characterization.

Authors:  A Srinatha; J K Pandit; S Singh
Journal:  Indian J Pharm Sci       Date:  2008-01       Impact factor: 0.975

4.  Improved bioavailability through floating microspheres of lovastatin.

Authors:  S Kumar; K Nagpal; Sk Singh; Dn Mishra
Journal:  Daru       Date:  2011       Impact factor: 3.117

5.  Chitosan-based Floating Microspheres of Trimetazidin Dihydrochloride; Preparation and In vitro Characterization.

Authors:  H M El-Nahas; K M Hosny
Journal:  Indian J Pharm Sci       Date:  2011-07       Impact factor: 0.975

Review 6.  Preparation, characterization, and potential application of chitosan, chitosan derivatives, and chitosan metal nanoparticles in pharmaceutical drug delivery.

Authors:  Tarek A Ahmed; Bader M Aljaeid
Journal:  Drug Des Devel Ther       Date:  2016-01-28       Impact factor: 4.162

7.  Modulation of Entrapment Efficiency and In Vitro Release Properties of BSA-Loaded Chitosan Microparticles Cross-Linked with Citric Acid as a Potential Protein-Drug Delivery System.

Authors:  Natalia Sedyakina; Andrey Kuskov; Kelly Velonia; Nataliya Feldman; Sergey Lutsenko; Grigory Avramenko
Journal:  Materials (Basel)       Date:  2020-04-24       Impact factor: 3.623

8.  Utilization of propranolol hydrochloride mucoadhesive invasomes as a locally acting contraceptive: in-vitro, ex-vivo, and in-vivo evaluation.

Authors:  Mahmoud H Teaima; Moaz A Eltabeeb; Mohamed A El-Nabarawi; Menna M Abdellatif
Journal:  Drug Deliv       Date:  2022-12       Impact factor: 6.819

Review 9.  Chitosan Nanoparticles: A Versatile Platform for Biomedical Applications.

Authors:  Showkeen Muzamil Bashir; Gulzar Ahmed Rather; Ana Patrício; Zulfiqar Haq; Amir Amin Sheikh; Mohd Zahoor Ul Haq Shah; Hemant Singh; Azmat Alam Khan; Sofi Imtiyaz; Sheikh Bilal Ahmad; Showket Nabi; Rabia Rakhshan; Saqib Hassan; Pedro Fonte
Journal:  Materials (Basel)       Date:  2022-09-20       Impact factor: 3.748

10.  Increased ROS Scavenging and Antioxidant Efficiency of Chlorogenic Acid Compound Delivered via a Chitosan Nanoparticulate System for Efficient In Vitro Visualization and Accumulation in Human Renal Adenocarcinoma Cells.

Authors:  Revathi Kavi Rajan; Mohd Zobir Hussein; Sharida Fakurazi; Khatijah Yusoff; Mas Jaffri Masarudin
Journal:  Int J Mol Sci       Date:  2019-09-20       Impact factor: 5.923
  10 in total

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