Literature DB >> 8807894

Loss of functional prion protein: a role in prion disorders?

D R Borchelt1, S S Sisodia.   

Abstract

To understand the normal function of the prion protein (PrP) and its role in prion disorders, several groups have generated mice lacking PrP. Some of these mice develop symptoms associated with prion diseases, but other experimental evidence suggests that the loss of functional PrP is not the instigating factor in these disorders.

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Year:  1996        PMID: 8807894     DOI: 10.1016/s1074-5521(96)90128-3

Source DB:  PubMed          Journal:  Chem Biol        ISSN: 1074-5521


  6 in total

Review 1.  Allosteric function and dysfunction of the prion protein.

Authors:  Rafael Linden; Yraima Cordeiro; Luis Mauricio T R Lima
Journal:  Cell Mol Life Sci       Date:  2011-10-09       Impact factor: 9.261

Review 2.  Rodent Models of Amyotrophic Lateral Sclerosis.

Authors:  Thomas Philips; Jeffrey D Rothstein
Journal:  Curr Protoc Pharmacol       Date:  2015-06-01

Review 3.  SOD1 and TDP-43 animal models of amyotrophic lateral sclerosis: recent advances in understanding disease toward the development of clinical treatments.

Authors:  Peter I Joyce; Pietro Fratta; Elizabeth M C Fisher; Abraham Acevedo-Arozena
Journal:  Mamm Genome       Date:  2011-06-26       Impact factor: 2.957

4.  A high-fat jelly diet restores bioenergetic balance and extends lifespan in the presence of motor dysfunction and lumbar spinal cord motor neuron loss in TDP-43A315T mutant C57BL6/J mice.

Authors:  Karen S Coughlan; Luise Halang; Ina Woods; Jochen H M Prehn
Journal:  Dis Model Mech       Date:  2016-08-04       Impact factor: 5.758

5.  Methodology Aspects of Colony Maintain for a Murine Model of Amyotrophic Lateral Sclerosis (ALS) TDP-43 Proteinopathy.

Authors:  César Álvaro-Alonso; Águeda Ferrer-Donato; Elizabeth Fernández-Torres; Mónica Carballo-Villa; Carmen M Fernandez-Martos
Journal:  Animals (Basel)       Date:  2020-12-07       Impact factor: 2.752

6.  Behavioral characterization of mouse models of neuroferritinopathy.

Authors:  Sara Capoccia; Federica Maccarinelli; Barbara Buffoli; Luigi F Rodella; Ottavio Cremona; Paolo Arosio; Francesca Cirulli
Journal:  PLoS One       Date:  2015-02-17       Impact factor: 3.240

  6 in total

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