Literature DB >> 8807842

Short strong hydrogen bonds: can they explain enzymic catalysis?

J P Guthrie1.   

Abstract

It has been proposed that some remarkable enzymic catalytic effects can be explained by the existence of unusually strong hydrogen bonds within the enzyme's active site. Although such hydrogen bonds may be short, and may have unusual properties, there is no evidence that unusually strong hydrogen bonds exist in solution or in enzyme active sites. Thus there is no basis for invoking strong hydrogen bonds to explain enzymic rate enhancements.

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Year:  1996        PMID: 8807842     DOI: 10.1016/s1074-5521(96)90258-6

Source DB:  PubMed          Journal:  Chem Biol        ISSN: 1074-5521


  17 in total

1.  The role of hydrogen bonding in the enzymatic reaction catalyzed by HIV-1 protease.

Authors:  Joanna Trylska; Pawel Grochowski; J Andrew McCammon
Journal:  Protein Sci       Date:  2004-02       Impact factor: 6.725

2.  Crystal structure of HIV-1 protease in situ product complex and observation of a low-barrier hydrogen bond between catalytic aspartates.

Authors:  Amit Das; Vishal Prashar; Smita Mahale; L Serre; J-L Ferrer; M V Hosur
Journal:  Proc Natl Acad Sci U S A       Date:  2006-11-20       Impact factor: 11.205

3.  Strong ionic hydrogen bonding causes a spectral isotope effect in photoactive yellow protein.

Authors:  Sandip Kaledhonkar; Miwa Hara; T Page Stalcup; Aihua Xie; Wouter D Hoff
Journal:  Biophys J       Date:  2013-12-03       Impact factor: 4.033

4.  Hydrogen bond design principles.

Authors:  Lucas J Karas; Chia-Hua Wu; Ranjita Das; Judy I-Chia Wu
Journal:  Wiley Interdiscip Rev Comput Mol Sci       Date:  2020-05-16

5.  Proton affinity of the oxyanion hole in the active site of ketosteroid isomerase.

Authors:  William Childs; Steven G Boxer
Journal:  Biochemistry       Date:  2010-03-30       Impact factor: 3.162

6.  Consequences of breaking the Asp-His hydrogen bond of the catalytic triad: effects on the structure and dynamics of the serine esterase cutinase.

Authors:  E Y Lau; T C Bruice
Journal:  Biophys J       Date:  1999-07       Impact factor: 4.033

7.  NMR evidence for the participation of a low-barrier hydrogen bond in the mechanism of delta 5-3-ketosteroid isomerase.

Authors:  Q Zhao; C Abeygunawardana; P Talalay; A S Mildvan
Journal:  Proc Natl Acad Sci U S A       Date:  1996-08-06       Impact factor: 11.205

8.  Serine protease acylation proceeds with a subtle re-orientation of the histidine ring at the tetrahedral intermediate.

Authors:  Yanzi Zhou; Yingkai Zhang
Journal:  Chem Commun (Camb)       Date:  2010-11-29       Impact factor: 6.222

9.  Catalytic role of enzymes: short strong H-bond-induced partial proton shuttles and charge redistributions.

Authors:  K S Kim; K S Oh; J Y Lee
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-06       Impact factor: 11.205

10.  Ligand-Induced Proton Transfer and Low-Barrier Hydrogen Bond Revealed by X-ray Crystallography.

Authors:  Derek A Nichols; Jacqueline C Hargis; Ruslan Sanishvili; Priyadarshini Jaishankar; Kyle Defrees; Emmanuel W Smith; Kenneth K Wang; Fabio Prati; Adam R Renslo; H Lee Woodcock; Yu Chen
Journal:  J Am Chem Soc       Date:  2015-06-22       Impact factor: 15.419

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