OBJECTIVE: Diabetic patients (DP) refer increased hunger sensation (HS) when hyperglycemic but not yet ketogenic. As HS shows a within-day (ultradian cyclicity) and intra-day (circadian cyclicity) repetitivity, its recursive pattern was investigated in patients with type 1 and type 2 diabetes mellitus (DM), in compensated and uncompensated metabolic stage. METHOD: HS was approached in its cyclic structure by means of spectral analysis (SA), and in its circadian rhythmicity by means of Single Cosinor analysis (SCA), applied to self-rated scores of HS given every 30 min to their HS (orexigram) by DP. RESULTS: Exaggerated periprandial, interprandial, and/or nocturnal peaks of HS were seen in the orexigram of both the type I and type II DP. Specific alterations in HS periodogram were detected, structurally denoting a relative prevalence of the ultradian components along with the deamplification and loss of the circadian harmonics. DISCUSSION: The increase of HS (hyperorexia) in nonketotic DM may be formally attributed to a mechanism of frequency multiplication and amplitude demodulation in the multifrequency bioperiodic structure which physiologically regulates the recursive pattern to the daily HS in human beings.
OBJECTIVE:Diabeticpatients (DP) refer increased hunger sensation (HS) when hyperglycemic but not yet ketogenic. As HS shows a within-day (ultradian cyclicity) and intra-day (circadian cyclicity) repetitivity, its recursive pattern was investigated in patients with type 1 and type 2 diabetes mellitus (DM), in compensated and uncompensated metabolic stage. METHOD: HS was approached in its cyclic structure by means of spectral analysis (SA), and in its circadian rhythmicity by means of Single Cosinor analysis (SCA), applied to self-rated scores of HS given every 30 min to their HS (orexigram) by DP. RESULTS: Exaggerated periprandial, interprandial, and/or nocturnal peaks of HS were seen in the orexigram of both the type I and type II DP. Specific alterations in HS periodogram were detected, structurally denoting a relative prevalence of the ultradian components along with the deamplification and loss of the circadian harmonics. DISCUSSION: The increase of HS (hyperorexia) in nonketotic DM may be formally attributed to a mechanism of frequency multiplication and amplitude demodulation in the multifrequency bioperiodic structure which physiologically regulates the recursive pattern to the daily HS in human beings.
Authors: G Fatati; A L Vendetli; A Puxeddu; G P De Francesco; S Coda; R De Rosa; E De Marco; T De Laurentis; S Fontana; P Cugini Journal: Eat Weight Disord Date: 2001-12 Impact factor: 4.652
Authors: P Cugini; M Cilli; A Salandri; P Ceccotti; A Di Marzo; A Rodio; S Fontana; A M Pellegrino; G P De Francesco; S Coda; F De Vito; L Colosi; C M Petrangeli; C Giovannini Journal: Eat Weight Disord Date: 1999-09 Impact factor: 4.652
Authors: P Cugini; A Salandri; M Cilli; P Ceccotti; A Di Marzo; A Rodio; F Marcianò; S Fontana; A M Pellegrino; K Vacca; G Di Siena; G P Di Francesco; S Coda; C M Petrangeli; C Giovannini Journal: Eat Weight Disord Date: 1998-12 Impact factor: 4.652