Human enzyme polymorphism in the Canary Islands. VII. G6PD Seattle in Canarians and North African Berbers.

Sequence analysis of the glucose-6-phosphate dehydrogenase (G6PD) variant Gc, characterized by slower electrophoretic mobility than G6PD-B, in 14 Canarian and 2 Berber males, has revealed that all of them share the G-->C mutation at nucleotide 844 in exon 8 leading to an Asp-->His substitution at amino acid 282 known as G6PD Seattle. No additional differences have been detected among them nor with the common haplotype previously found for this variant.