Literature DB >> 8807069

Enhanced oxidative killing of azole-resistant Candida glabrata strains with ERG11 deletion.

V L Kan1, A Geber, J E Bennett.   

Abstract

The susceptibility of genetically defined Candida glabrata strains to killing by H2O2 and neutrophils was assessed. Fluconazole-susceptible L5L and L5D strains demonstrated survival rates higher than those of two fluconazole-resistant strains lacking the ERG11 gene coding for 14 alpha-demethylase. Fluconazole resistance can occur by mechanisms which increase fungal susceptibility to oxidative killing by H2O2 and neutrophils.

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Year:  1996        PMID： 8807069      PMCID： PMC163402     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

1.  Defective sterol C5-6 desaturation and azole resistance: a new hypothesis for the mode of action of azole antifungals.

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Journal:  Biochem Biophys Res Commun       Date:  1989-11-15       Impact factor: 3.575

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Journal:  AIDS       Date:  1992-06       Impact factor: 4.177

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Journal:  Lancet       Date:  1986-08-02       Impact factor: 79.321

Review 5.  Overview of host defenses in fungal infections.

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Journal:  Clin Infect Dis       Date:  1992-03       Impact factor: 9.079

6.  The activity of ketoconazole in mixed cultures of leukocytes and Candida albicans.

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Journal:  Sabouraudia       Date:  1980-09

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Journal:  J Infect Dis       Date:  1978-01       Impact factor: 5.226

8.  Phagocyte-mediated killing of Candida tropicalis.

Authors:  R A Lindemann; C K Franker
Journal:  Mycopathologia       Date:  1991-02       Impact factor: 2.574

9.  Deletion of the Candida glabrata ERG3 and ERG11 genes: effect on cell viability, cell growth, sterol composition, and antifungal susceptibility.

Authors:  A Geber; C A Hitchcock; J E Swartz; F S Pullen; K E Marsden; K J Kwon-Chung; J E Bennett
Journal:  Antimicrob Agents Chemother       Date:  1995-12       Impact factor: 5.191

10.  Fluconazole in the management of oropharyngeal candidosis in a predominantly HIV antibody-positive group of patients.

Authors:  B Dupont; E Drouhet
Journal:  J Med Vet Mycol       Date:  1988-02
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  10 in total

Review 1.  Clinical, cellular, and molecular factors that contribute to antifungal drug resistance.

Authors:  T C White; K A Marr; R A Bowden
Journal:  Clin Microbiol Rev       Date:  1998-04       Impact factor: 26.132

2.  Evaluation of differential gene expression in fluconazole-susceptible and -resistant isolates of Candida albicans by cDNA microarray analysis.

Authors:  P David Rogers; Katherine S Barker
Journal:  Antimicrob Agents Chemother       Date:  2002-11       Impact factor: 5.191

3.  Stable phenotypic resistance of Candida species to amphotericin B conferred by preexposure to subinhibitory levels of azoles.

Authors:  J A Vazquez; M T Arganoza; D Boikov; S Yoon; J D Sobel; R A Akins
Journal:  J Clin Microbiol       Date:  1998-09       Impact factor: 5.948

4.  Transcriptional profiling of Candida glabrata during phagocytosis by neutrophils and in the infected mouse spleen.

Authors:  Yuichi Fukuda; Huei-Fung Tsai; Timothy G Myers; John E Bennett
Journal:  Infect Immun       Date:  2013-02-12       Impact factor: 3.441

5.  Genome-wide expression profile analysis reveals coordinately regulated genes associated with stepwise acquisition of azole resistance in Candida albicans clinical isolates.

Authors:  P David Rogers; Katherine S Barker
Journal:  Antimicrob Agents Chemother       Date:  2003-04       Impact factor: 5.191

6.  Inhibition of hyphal growth of azole-resistant strains of Candida albicans by triazole antifungal agents in the presence of lactoferrin-related compounds.

Authors:  H Wakabayashi; S Abe; S Teraguchi; H Hayasawa; H Yamaguchi
Journal:  Antimicrob Agents Chemother       Date:  1998-07       Impact factor: 5.191

7.  Aspartyl proteases in Candida glabrata are required for suppression of the host innate immune response.

Authors:  Mubashshir Rasheed; Anamika Battu; Rupinder Kaur
Journal:  J Biol Chem       Date:  2018-02-28       Impact factor: 5.157

8.  Coordinated Regulation of Membrane Homeostasis and Drug Accumulation by Novel Kinase STK-17 in Response to Antifungal Azole Treatment.

Authors:  Chengcheng Hu; Mi Zhou; Xianhe Cao; Wei Xue; Zhenying Zhang; Shaojie Li; Xianyun Sun
Journal:  Microbiol Spectr       Date:  2022-02-23

9.  Immune evasion, stress resistance, and efficient nutrient acquisition are crucial for intracellular survival of Candida glabrata within macrophages.

Authors:  Katja Seider; Franziska Gerwien; Lydia Kasper; Stefanie Allert; Sascha Brunke; Nadja Jablonowski; Tobias Schwarzmüller; Dagmar Barz; Steffen Rupp; Karl Kuchler; Bernhard Hube
Journal:  Eukaryot Cell       Date:  2013-12-20

10.  ERG3 and ERG11 genes are critical for the pathogenesis of Candida albicans during the oral mucosal infection.

Authors:  Yujie Zhou; Min Liao; Chengguang Zhu; Yao Hu; Ting Tong; Xian Peng; Mingyun Li; Mingye Feng; Lei Cheng; Biao Ren; Xuedong Zhou
Journal:  Int J Oral Sci       Date:  2018-03-16       Impact factor: 6.344
  10 in total

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