Literature DB >> 8806665

4-hydroxy-2,3-trans-nonenal induces transcription and expression of aldose reductase.

S Spycher1, S Tabataba-Vakili, V B O'Donnell, L Palomba, A Azzi.   

Abstract

Treatment of A7r5 rat vascular smooth muscle cells with 4-hydroxy-2,3-trans-nonenal (HNE) resulted in increased aldose reductase mRNA transcription. Induction was time dependent, reaching a maximum (2,3-fold) after 7 hours. An enzymatically active aldose reductase analysed by Western blotting and enzyme assays was expressed. Sorbinil, an aldose reductase inhibitor, induced a significant enhancement of HNE cytotoxicity, indicating a protective role of aldose reductase against HNE-induced A7r5 cell death. These data indicate that induction of aldose reductase by HNE may represent an important cellular defence mechanism against oxidative injury.

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Year:  1996        PMID： 8806665     DOI： 10.1006/bbrc.1996.1386

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  15 in total

1.  Metabolism of the lipid peroxidation product, 4-hydroxy-trans-2-nonenal, in isolated perfused rat heart.

Authors:  S Srivastava; A Chandra; L F Wang; W E Seifert; B B DaGue; N H Ansari; S K Srivastava; A Bhatnagar
Journal:  J Biol Chem       Date:  1998-05-01       Impact factor: 5.157

Review 2.  Oxidative stress, inflammation and carcinogenesis are controlled through the pentose phosphate pathway by transaldolase.

Authors:  Andras Perl; Robert Hanczko; Tiffany Telarico; Zachary Oaks; Steve Landas
Journal:  Trends Mol Med       Date:  2011-03-02       Impact factor: 11.951

3.  Increase in class 2 aldehyde dehydrogenase expression by arachidonic acid in rat hepatoma cells.

Authors:  R A Canuto; M Ferro; R A Salvo; A M Bassi; A Trombetta; M Maggiora; G Martinasso; R Lindahl; G Muzio
Journal:  Biochem J       Date:  2001-08-01       Impact factor: 3.857

Review 4.  Aldose reductase inhibition suppresses oxidative stress-induced inflammatory disorders.

Authors:  Satish K Srivastava; Umesh C S Yadav; Aramati B M Reddy; Ashish Saxena; Ravinder Tammali; Mohammad Shoeb; Naseem H Ansari; Aruni Bhatnagar; Mark J Petrash; Sanjay Srivastava; Kota V Ramana
Journal:  Chem Biol Interact       Date:  2011-02-24       Impact factor: 5.192

5.  Aldose reductase functions as a detoxification system for lipid peroxidation products in vasculitis.

Authors:  H L Rittner; V Hafner; P A Klimiuk; L I Szweda; J J Goronzy; C M Weyand
Journal:  J Clin Invest       Date:  1999-04       Impact factor: 14.808

6.  Identification of biochemical pathways for the metabolism of oxidized low-density lipoprotein derived aldehyde-4-hydroxy trans-2-nonenal in vascular smooth muscle cells.

Authors:  S Srivastava; D J Conklin; S Q Liu; N Prakash; P J Boor; S K Srivastava; A Bhatnagar
Journal:  Atherosclerosis       Date:  2001-10       Impact factor: 5.162

7.  Prevention of diabetes-induced albuminuria in transgenic rats overexpressing human aldose reductase.

Authors:  Daniel P K Ng; Charles L Hardy; Wendy C Burns; Evelyne E Muggli; Nicole Kerr; Jane McCausland; Daine Alcorn; Timothy E Adams; Jeffrey D Zajac; Richard G Larkins; Marjorie E Dunlop
Journal:  Endocrine       Date:  2002-06       Impact factor: 3.633

8.  Overexpression of Aldose Reductase Render Mouse Hepatocytes More Sensitive to Acetaminophen Induced Oxidative Stress and Cell Death.

Authors:  Munzir M E Ahmed; J A S Al-Obosi; H M Osman; M E Shayoub
Journal:  Indian J Clin Biochem       Date:  2015-09-30

Review 9.  The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal.

Authors:  Henry Jay Forman; Jon M Fukuto; Tom Miller; Hongqiao Zhang; Alessandra Rinna; Smadar Levy
Journal:  Arch Biochem Biophys       Date:  2008-06-24       Impact factor: 4.013

10.  The generation of 4-hydroxynonenal, an electrophilic lipid peroxidation end product, in rabbit cornea organ cultures treated with UVB light and nitrogen mustard.

Authors:  Ruijin Zheng; Iris Po; Vladimir Mishin; Adrienne T Black; Diane E Heck; Debra L Laskin; Patrick J Sinko; Donald R Gerecke; Marion K Gordon; Jeffrey D Laskin
Journal:  Toxicol Appl Pharmacol       Date:  2013-07-09       Impact factor: 4.219
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