Literature DB >> 8805238

Failure to unwind causes cancer. Genome stability.

P M Watt1, I D Hickson.   

Abstract

The recent cloning of the gene defective in individuals with Bloom's syndrome has revealed a link between DNA helicases, genetic instability and a predisposition to cancer.

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Year:  1996        PMID： 8805238     DOI： 10.1016/s0960-9822(02)00474-8

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


  14 in total

1.  Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs.

Authors:  R M Brosh; J K Karow; E J White; N D Shaw; I D Hickson; V A Bohr
Journal:  Nucleic Acids Res       Date:  2000-06-15       Impact factor: 16.971

2.  The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci.

Authors:  C Frei; S M Gasser
Journal:  Genes Dev       Date:  2000-01-01       Impact factor: 11.361

3.  The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination.

Authors:  M McVey; M Kaeberlein; H A Tissenbaum; L Guarente
Journal:  Genetics       Date:  2001-04       Impact factor: 4.562

4.  SGS1, a homologue of the Bloom's and Werner's syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiae.

Authors:  P M Watt; I D Hickson; R H Borts; E J Louis
Journal:  Genetics       Date:  1996-11       Impact factor: 4.562

5.  Evolution of the RECQ family of helicases: A drosophila homolog, Dmblm, is similar to the human bloom syndrome gene.

Authors:  K Kusano; M E Berres; W R Engels
Journal:  Genetics       Date:  1999-03       Impact factor: 4.562

6.  The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivo.

Authors:  Cyril Ribeyre; Judith Lopes; Jean-Baptiste Boulé; Aurèle Piazza; Aurore Guédin; Virginia A Zakian; Jean-Louis Mergny; Alain Nicolas
Journal:  PLoS Genet       Date:  2009-05-08       Impact factor: 5.917

7.  PML colocalizes with and stabilizes the DNA damage response protein TopBP1.

Authors:  Zhi-Xiang Xu; Anna Timanova-Atanasova; Rui-Xun Zhao; Kun-Sang Chang
Journal:  Mol Cell Biol       Date:  2003-06       Impact factor: 4.272

8.  Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene.

Authors:  N Chester; F Kuo; C Kozak; C D O'Hara; P Leder
Journal:  Genes Dev       Date:  1998-11-01       Impact factor: 11.361

9.  Bloom's syndrome protein, BLM, colocalizes with replication protein A in meiotic prophase nuclei of mammalian spermatocytes.

Authors:  D Walpita; A W Plug; N F Neff; J German; T Ashley
Journal:  Proc Natl Acad Sci U S A       Date:  1999-05-11       Impact factor: 11.205

10.  Regulation and localization of the Bloom syndrome protein in response to DNA damage.

Authors:  O Bischof; S H Kim; J Irving; S Beresten; N A Ellis; J Campisi
Journal:  J Cell Biol       Date:  2001-04-16       Impact factor: 10.539
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