| Literature DB >> 8804977 |
S B Mannheimer1, J Hariprashad, M Y Stoeckle, H W Murray.
Abstract
To determine if monocyte chemotactic and activating factor (MCAF) induces intracellular antimicrobial activity, human monocyte-derived macrophages were treated with MCAF and challenged with Toxoplasma gondii and Leishmania donovani. Pretreatment with MCAF induced macrophages to inhibit protozoal replication by approximately 50%. These findings suggest a potential host defense role for MCAF in the inflammatory response to intracellular pathogens.Entities:
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Year: 1996 PMID： 8804977 DOI： 10.1111/j.1574-695X.1996.tb00268.x
Source DB: PubMed Journal: FEMS Immunol Med Microbiol ISSN： 0928-8244