Literature DB >> 8804532

Sculpted immunogens; B-cell epitope optimization using constrained secondary structure libraries.

J Urban1, M Qabar, C Sia, M Klein, M Kahn.   

Abstract

A library of conformationally constrained reverse turn mimetics of the HIV V3 loop was screened against the mAb 50.1. Addition of a Th-cell epitope to the reverse turn template provided an immunogen which, when immunized (either in alum or IFA), generated a high titer, highly specific response to HIV gp 120.

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Year:  1996        PMID: 8804532     DOI: 10.1016/0968-0896(96)00062-4

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN: 0968-0896            Impact factor:   3.641


  1 in total

Review 1.  Peptide and peptidomimetic libraries. Molecular diversity and drug design.

Authors:  F al-Obeidi; V J Hruby; T K Sawyer
Journal:  Mol Biotechnol       Date:  1998-06       Impact factor: 2.695

  1 in total

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