Literature DB >> 8804422

IL4 and IL13 receptors share the gamma c chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells.

C Rolling1, D Treton, S Pellegrini, P Galanaud, Y Richard.   

Abstract

IL13 induces the same biological effects as IL4 in normal human B cells. We show that as in the IL4R complex, both IL4R alpha and IL2R gamma c are components of the IL13R and that both cytokines induced STAT6, STAT3 and STAT5 activation in B cells. In spite of this similar downstream signalling, IL4 and IL13 used a different set of Janus kinases: IL13 is unable to activate JAK1 and JAK3.

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Year:  1996        PMID： 8804422     DOI： 10.1016/0014-5793(96)00835-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  24 in total

1.  IL-4 abrogates osteoclastogenesis through STAT6-dependent inhibition of NF-kappaB.

Authors:  Y Abu-Amer
Journal:  J Clin Invest       Date:  2001-06       Impact factor: 14.808

2.  IL13 activates autophagy to regulate secretion in airway epithelial cells.

Authors:  John D Dickinson; Yael Alevy; Nicole P Malvin; Khushbu K Patel; Sean P Gunsten; Michael J Holtzman; Thaddeus S Stappenbeck; Steven L Brody
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Review 3.  Monoclonal antibodies for the treatment of severe asthma.

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4.  Association of serum cytokines with colorectal polyp number and type in adult males.

Authors:  Sarah S Comstock; Diana Xu; Kari Hortos; Bruce Kovan; Sarah McCaskey; Dorothy R Pathak; Jenifer I Fenton
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5.  Unusual asthma syndromes and their management.

Authors:  Jaymin B Morjaria; Jack A Kastelik
Journal:  Ther Adv Chronic Dis       Date:  2011-07       Impact factor: 5.091

6.  IL-9 induces CCL11 expression via STAT3 signalling in human airway smooth muscle cells.

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7.  IL-21 is expressed in Hodgkin lymphoma and activates STAT5: evidence that activated STAT5 is required for Hodgkin lymphomagenesis.

Authors:  Ferenc A Scheeren; Sean A Diehl; Laura A Smit; Tim Beaumont; Marianne Naspetti; Richard J Bende; Bianca Blom; Kennosuke Karube; Koichi Ohshima; Carel J M van Noesel; Hergen Spits
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8.  STAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation.

Authors:  Sean A Diehl; Heike Schmidlin; Maho Nagasawa; Simon D van Haren; Mark J Kwakkenbos; Etsuko Yasuda; Tim Beaumont; Ferenc A Scheeren; Hergen Spits
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9.  c-Src tyrosine kinase co-associates with and phosphorylates signal transducer and activator of transcription 5b which mediates the proliferation of normal human B lymphocytes.

Authors:  M-P Cayer; M Proulx; X-Z Ma; D Sakac; J-F Giguère; M Drouin; S Néron; D R Branch; D Jung
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10.  Janus kinase 3 activity is necessary for phosphorylation of cytosolic phospholipase A2 and prostaglandin E2 synthesis by macrophages infected with Francisella tularensis live vaccine strain.

Authors:  Ashley M Brummett; Aaron R Navratil; Joshua D Bryan; Matthew D Woolard
Journal:  Infect Immun       Date:  2013-12-16       Impact factor: 3.441
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