Migraine and sickle-cell disorders: is there a cause for concern?

Migraine and sickle-cell disease are common diseases, and may coexist in the same individual. Such a chance association is potentially dangerous because the two disorders may act synergistically to cause major neurological complications which may be permanent and contribute to the well-known mortality of sickle-cell disease. In theory, it is possible to minimize the risk of adverse sequelae of this combination of common maladies.