Literature DB >> 8803820

Apolipoprotein E genotype and concomitant clinical features in early-onset Alzheimer's disease.

J Bronzova1, C M van Duijn, L M Havekes, P de Knijff, C Van Broeckhoven, A Hofman.   

Abstract

We have studied the relationship between the apolipoprotein E gene (APOE) and the development of myoclonus, tremors, rigidity and seizures in 168 patients with probable early-onset Alzheimer's disease (AD). There was a statistically significantly lower risk of tremor for carriers of the epsilon 4 allele of APOE. This allele was also associated with an increased risk of myoclonus. Our findings suggest that there may be differences in progression and clinical appearance in early-onset AD related to the APOE genotype.

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Year:  1996        PMID： 8803820     DOI： 10.1007/bf00900501

Source DB:  PubMed          Journal:  J Neurol        ISSN： 0340-5354            Impact factor:   4.849


  15 in total

1.  Clinical features and mortality in patients with early-onset Alzheimer's disease.

Authors:  W N Samson; C M van Duijn; W C Hop; A Hofman
Journal:  Eur Neurol       Date:  1996       Impact factor: 1.710

2.  Seizures and myoclonus in patients with Alzheimer's disease.

Authors:  W A Hauser; M L Morris; L L Heston; V E Anderson
Journal:  Neurology       Date:  1986-09       Impact factor: 9.910

3.  On estimating survival; a tale of two censors.

Authors:  J F Kurtzke
Journal:  J Clin Epidemiol       Date:  1989       Impact factor: 6.437

4.  Apolipoprotein E, survival in Alzheimer's disease patients, and the competing risks of death and Alzheimer's disease.

Authors:  E H Corder; A M Saunders; W J Strittmatter; D E Schmechel; P C Gaskell; J B Rimmler; P A Locke; P M Conneally; K E Schmader; R E Tanzi
Journal:  Neurology       Date:  1995-07       Impact factor: 9.910

5.  The apolipoprotein E epsilon 2 allele is associated with an increased risk of early-onset Alzheimer's disease and a reduced survival.

Authors:  C M van Duijn; P de Knijff; A Wehnert; J De Voecht; J B Bronzova; L M Havekes; A Hofman; C Van Broeckhoven
Journal:  Ann Neurol       Date:  1995-05       Impact factor: 10.422

6.  Utility of extrapyramidal signs and psychosis as predictors of cognitive and functional decline, nursing home admission, and death in Alzheimer's disease: prospective analyses from the Predictors Study.

Authors:  Y Stern; M Albert; J Brandt; D M Jacobs; M X Tang; K Marder; K Bell; M Sano; D P Devanand; F Bylsma
Journal:  Neurology       Date:  1994-12       Impact factor: 9.910

7.  Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Authors:  W J Strittmatter; A M Saunders; D Schmechel; M Pericak-Vance; J Enghild; G S Salvesen; A D Roses
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-01       Impact factor: 11.205

8.  Apolipoprotein E, epsilon 4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region.

Authors:  M C Chartier-Harlin; M Parfitt; S Legrain; J Pérez-Tur; T Brousseau; A Evans; C Berr; O Vidal; P Roques; V Gourlet
Journal:  Hum Mol Genet       Date:  1994-04       Impact factor: 6.150

9.  Apolipoprotein epsilon 4 allele and disease progression in patients with late-onset Alzheimer's disease.

Authors:  H Basun; M Grut; B Winblad; L Lannfelt
Journal:  Neurosci Lett       Date:  1995-01-02       Impact factor: 3.046

10.  Evidence that the APOE locus influences rate of disease progression in late onset familial Alzheimer's Disease but is not causative.

Authors:  C Bennett; F Crawford; A Osborne; P Diaz; J Hoyne; R Lopez; P Roques; R Duara; M Rossor; M Mullan
Journal:  Am J Med Genet       Date:  1995-02-27
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