| Literature DB >> 880251 |
R F Sherwood, J K Baird, T Atkinson, C N Wiblin, D A Rutter, D C Ellwood.
Abstract
Conjugation of carboxypeptidase G and arginase, two enzymes of therapeutic interest, to a soluble dextran significantly enhanced plasma persistence in normal and tumour-bearing mice. A prolonged decrease in arginine concentrations in plasma of tumour-bearing mice was demonstrated by using the dextran-linked arginase. Gel filtration of dextran-enzyme conjugate showed that enzyme activity co-chromatographed as a single peak with carbohydrate, and enzyme was shown to be covalently linked to the dextran.Entities:
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Year: 1977 PMID： 880251 PMCID： PMC1164813 DOI： 10.1042/bj1640461
Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857