Literature DB >> 880235

Cellular transport of lysosomal enzymes: an alternative hypothesis.

J B Lloyd.   

Abstract

Hickman & Neufeld [(1972) Biochem, Biophys. Res. Commun. 49, 992-999] have proposed that lysosomal enzymes reach the lysosomes by means of exocytosis and subsequent pinocytic reincorporation. The results leading to this conclusion are re-assessed and an alternative explanation is advanced that relates to the necessity for membrane recycling in endocytic cells.

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Year:  1977        PMID： 880235      PMCID： PMC1164786          DOI： 10.1042/bj1640281

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  10 in total

1.  Concerning a possible mechanism for selective capture of cytoplasmic proteins by lysosomes.

Authors:  R T Dean
Journal:  Biochem Biophys Res Commun       Date:  1975-11-17       Impact factor: 3.575

2.  GOLGI APPARATUS AND LYSOSOMES.

Authors:  A B NOVIKOFF; E ESSNER; N QUINTANA
Journal:  Fed Proc       Date:  1964 Sep-Oct

3.  A hypothesis for I-cell disease: defective hydrolases that do not enter lysosomes.

Authors:  S Hickman; E F Neufeld
Journal:  Biochem Biophys Res Commun       Date:  1972-11-15       Impact factor: 3.575

4.  I-cell disease: biochemical studies.

Authors:  J G Leroy; M W Ho; M C MacBrinn; K Zielke; J Jacob; J S O'Brien
Journal:  Pediatr Res       Date:  1972-10       Impact factor: 3.756

5.  Rat-liver lysosomal beta-glucosidase: a membrane enzyme.

Authors:  C Beck; A L Tappel
Journal:  Biochim Biophys Acta       Date:  1968-01-08

Review 6.  Functions of lysosomes.

Authors:  C De Duve; R Wattiaux
Journal:  Annu Rev Physiol       Date:  1966       Impact factor: 19.318

7.  Latency of some glycosidases of rat liver lysosomes.

Authors:  R Burton; J B Lloyd
Journal:  Biochem J       Date:  1976-12-15       Impact factor: 3.857

8.  Evidence for specific recognition sites mediating clearance of lysosomal enzymes in vivo.

Authors:  P Stahl; H Six; J S Rodman; P Schlesinger; D R Tulsiani; O Touster
Journal:  Proc Natl Acad Sci U S A       Date:  1976-11       Impact factor: 11.205

9.  Increased levels of sialic acid associated with a sialidase deficiency in I-cell disease (mucolipidosis II) fibroblasts.

Authors:  G H Thomas; G E Tiller; L W Reynolds; C S Miller; J W Bace
Journal:  Biochem Biophys Res Commun       Date:  1976-07-12       Impact factor: 3.575

10.  Membrane flow during pinocytosis. A stereologic analysis.

Authors:  R M Steinman; S E Brodie; Z A Cohn
Journal:  J Cell Biol       Date:  1976-03       Impact factor: 10.539
  10 in total
  8 in total

1.  Excretion-reuptake route of beta-hexosaminidase in normal and I-cell disease cultured fibroblasts.

Authors:  G D Vladutiu; M C Rattazzi
Journal:  J Clin Invest       Date:  1979-04       Impact factor: 14.808

2.  New form of acid phosphatase during lysosome biogenesis.

Authors:  G R Rao; H N Aithal; F G Toback; G S Getz
Journal:  Biochem J       Date:  1981-07-15       Impact factor: 3.857

3.  The effect of monensin on beta-hexosaminidase transport in normal and I-cell fibroblasts.

Authors:  G D Vladutiu; M C Rattazzi
Journal:  Biochem J       Date:  1980-12-15       Impact factor: 3.857

4.  Effect of tunicamycin and cycloheximide on the secretion of acid hydrolases from I-cell cultured fibroblasts.

Authors:  A L Miller; B C Kress; L Lewis; R Stein; C Kinnon
Journal:  Biochem J       Date:  1980-03-15       Impact factor: 3.857

5.  The hydrolysis of phosphatidylinositol by lysosomal enzymes of rat liver and brain.

Authors:  R F Irvine; N Hemington; R M Dawson
Journal:  Biochem J       Date:  1978-11-15       Impact factor: 3.857

6.  An alternative hypothesis of cellular transport of lysosomal enzymes in fibroblasts. Effect of inhibitors of lysosomal enzyme endocytosis on intra- and extra-cellular lysosomal enzyme activities.

Authors:  K von Figura; E Weber
Journal:  Biochem J       Date:  1978-12-15       Impact factor: 3.857

7.  Comparison of the alpha-mannosidases in fibroblast cultures from patients with mannosidosis and mucolipidosis II and from controls.

Authors:  D J Halley; B G Winchester; L J Burditt; A d'Azzo; D Robinson; H Galjaard
Journal:  Biochem J       Date:  1980-05-01       Impact factor: 3.857

8.  Correction of I-cell defect by hybridization with lysosomal enzyme deficient human fibroblasts.

Authors:  A d'Azzo; D J Halley; A Hoogeveen; H Galjaard
Journal:  Am J Hum Genet       Date:  1980-07       Impact factor: 11.025
  8 in total

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