Literature DB >> 8801572

Nitric oxide synthesis inhibition attenuates morphine-induced place preference.

T Kivastik1, J Rutkauskaite, A Zharkovsky.   

Abstract

Nitric oxide (NO) has been implicated in the actions of opioids. The aim of the present study was to investigate the role of NO in the mechanisms mediating the rewarding effects of morphine. Therefore, the influence of NO synthase inhibitor L-N-nitroarginine (L-NOARG) on morphine-induced place preference in rats was studied. L-NOARG, when given at 20 mg/kg, IP, significantly inhibited the effect of morphine. L-NOARG by itself, when administered at 5 or 20 mg/kg, IP, appeared to have no reliable effect on place conditioning. The results suggest a possible role of NO in the opioid reward process.

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Year:  1996        PMID： 8801572     DOI： 10.1016/0091-3057(95)02092-6

Source DB:  PubMed          Journal:  Pharmacol Biochem Behav        ISSN： 0091-3057            Impact factor:   3.533


  6 in total

1.  Reversal effect of intra-central amygdala microinjection of L-arginine on place aversion induced by naloxone in morphine conditioned rats.

Authors:  Sara Karimi; Manizheh Karami; Hedayat Sahraei; Mahnaz Rahimpour
Journal:  Iran Biomed J       Date:  2011

2.  Rewarding properties of sildenafil citrate in mice: role of the nitric oxide-cyclic GMP pathway.

Authors:  Pouya Tahsili-Fahadan; Noushin Yahyavi-Firouz-Abadi; Amir Hossein Orandi; Behnaz Esmaeili; Zahra Basseda; Ahmad Reza Dehpour
Journal:  Psychopharmacology (Berl)       Date:  2006-01-20       Impact factor: 4.530

Review 3.  Interactions between morphine and nitric oxide in various organs.

Authors:  Noboru Toda; Shiroh Kishioka; Yoshio Hatano; Hiroshi Toda
Journal:  J Anesth       Date:  2009-11-18       Impact factor: 2.078

4.  Supraspinally-administered agmatine attenuates the development of oral fentanyl self-administration.

Authors:  Carrie L Wade; Daniel J Schuster; Kristine M Domingo; Kelley F Kitto; Carolyn A Fairbanks
Journal:  Eur J Pharmacol       Date:  2008-04-08       Impact factor: 4.432

5.  Inhibition of PSD95-nNOS protein-protein interactions decreases morphine reward and relapse vulnerability in rats.

Authors:  Idaira Oliva; Shahin A Saberi; Claudia Rangel-Barajas; Vishakh Iyer; Kendra D Bunner; Yvonne Y Lai; Pushkar M Kulkarni; Sumanta Garai; Ganesh A Thakur; Jonathon D Crystal; George V Rebec; Andrea G Hohmann
Journal:  Addict Biol       Date:  2022-09       Impact factor: 4.093

6.  Nitric oxide in central amygdala potentiates expression of conditioned withdrawal induced by morphine.

Authors:  Manizheh Karami; Mahnaz Rahimpour; Sara Karimi; Hedayat Sahraei
Journal:  Indian J Pharmacol       Date:  2014 Jan-Feb       Impact factor: 1.200
  6 in total

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