Literature DB >> 8797710

Clonal expansion of infected cells: a way of life for HTLV-I.

E Wattel1, M Cavrois, A Gessain, S Wain-Hobson.   

Abstract

Human T-cell lymphotropic virus type I (HTLV-I) is characterized by a remarkable genetic stability and high proviral loads in the absence of malignant disease. This results from the effect of tax on cell cycling. The virus replicates essentially in concert with the cell that is, via mitosis, which can be shown by polymerase chain reaction amplification of the HTLV-I integration sites. This is true of all stages of HTLV-I infection and accompanies adult T-cell leukemia/lymphoma. The very low viremia results from its genetic organization.

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Year:  1996        PMID： 8797710     DOI： 10.1097/00042560-199600001-00016

Source DB:  PubMed          Journal:  J Acquir Immune Defic Syndr Hum Retrovirol        ISSN： 1077-9450


  34 in total

1.  HTLV-1 propels untransformed CD4 lymphocytes into the cell cycle while protecting CD8 cells from death.

Authors:  David Sibon; Anne-Sophie Gabet; Marc Zandecki; Christiane Pinatel; Julien Thête; Marie-Hélène Delfau-Larue; Samira Rabaaoui; Antoine Gessain; Olivier Gout; Steven Jacobson; Franck Mortreux; Eric Wattel
Journal:  J Clin Invest       Date:  2006-04       Impact factor: 14.808

2.  Multiple Pathways Control the Reactivation of Telomerase in HTLV-I-Associated Leukemia.

Authors:  Marcia Bellon; Christophe Nicot
Journal:  Int J Cancer Oncol       Date:  2015-06-02

3.  Quantification of proviral load of human immunodeficiency virus type 2 subtypes A and B using real-time PCR.

Authors:  F Damond; D Descamps; I Farfara; J N Telles; S Puyeo; P Campa; A Leprêtre; S Matheron; F Brun-Vezinet; F Simon
Journal:  J Clin Microbiol       Date:  2001-12       Impact factor: 5.948

4.  Two-step nature of human T-cell leukemia virus type 1 replication in experimentally infected squirrel monkeys (Saimiri sciureus).

Authors:  F Mortreux; M Kazanji; A S Gabet; B de Thoisy; E Wattel
Journal:  J Virol       Date:  2001-01       Impact factor: 5.103

Review 5.  Pathogenesis and treatment of HTLV-I associated myelopathy.

Authors:  G P Taylor
Journal:  Sex Transm Infect       Date:  1998-10       Impact factor: 3.519

6.  Effect of lamivudine on human T-cell leukemia virus type 1 (HTLV-1) DNA copy number, T-cell phenotype, and anti-tax cytotoxic T-cell frequency in patients with HTLV-1-associated myelopathy.

Authors:  G P Taylor; S E Hall; S Navarrete; C A Michie; R Davis; A D Witkover; M Rossor; M A Nowak; P Rudge; E Matutes; C R Bangham; J N Weber
Journal:  J Virol       Date:  1999-12       Impact factor: 5.103

7.  Stable and transient periodic oscillations in a mathematical model for CTL response to HTLV-I infection.

Authors:  John Lang; Michael Y Li
Journal:  J Math Biol       Date:  2011-07-27       Impact factor: 2.259

8.  Activation of human T-cell leukemia virus type 1 tax gene expression in chronically infected T cells.

Authors:  H C Lin; C S Dezzutti; R B Lal; A B Rabson
Journal:  J Virol       Date:  1998-07       Impact factor: 5.103

9.  Human T-cell lymphotropic virus type 1 tax among American blood donors.

Authors:  D Zucker-Franklin; B A Pancake
Journal:  Clin Diagn Lab Immunol       Date:  1998-11

10.  Human T-lymphotropic virus type 2 (HTLV-2) provirus in circulating cells of the monocyte/macrophage lineage in patients dually infected with human immunodeficiency virus type 1 and HTLV-2 and having predominantly sensory polyneuropathy.

Authors:  G Zehender; L Meroni; S Varchetta; C De Maddalena; B Cavalli; M Gianotto; A B Bosisio; C Colasante; G Rizzardini; M Moroni; M Galli
Journal:  J Virol       Date:  1998-09       Impact factor: 5.103
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