Literature DB >> 879764

Evaluation of three newer methods for investigating protein interactions of penicillin G.

L R Peterson, D N Gerding, H H Zinneman, B M Moore.   

Abstract

THE INTERACTION OF PENICILLIN G WITH HUMAN SERUM PROTEINS WAS EVALUATED BY THREE DIFFERENT TECHNIQUES: rate of dialysis, cross-linked dextran exclusion, and ultracentrifugation. The rate-of-dialysis technique demonstrated that penicillin G binding to serum was immediate but incompletely reversible. Cross-linked dextran adsorbed or trapped significant amounts of penicillin G, necessitating correction factors of more than 10%. Ultracentrifugation was found to be the most reliable method for quantitative protein-binding determinations of penicillins.

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Year:  1977        PMID： 879764      PMCID： PMC352116          DOI： 10.1128/AAC.11.6.993

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  30 in total

Review 1.  Binding of drugs to serum albumin (first of two parts).

Authors:  J Koch-Weser; E M Sellers
Journal:  N Engl J Med       Date:  1976-02-05       Impact factor: 91.245

2.  The binding of penicillin antibiotics to a human liver protein.

Authors:  M L Kornguth; R A Monson; C M Kunin
Journal:  Arch Biochem Biophys       Date:  1976-05       Impact factor: 4.013

3.  [METHODS OF DETERMINATION AND REGULARITIES IN PROTEIN BINDING OF SULFONAMIDES AND PENICILLINS].

Authors:  W SCHOLTAN
Journal:  Antibiot Chemother       Date:  1964

4.  The Relation of Protein Binding to the Pharmacology and Antibacterial Activity of Penicillins X, G, Dihydro F, and K.

Authors:  R Tompsett; S Shultz; W McDermott
Journal:  J Bacteriol       Date:  1947-05       Impact factor: 3.490

5.  Clinical pharmacology of the new penicillins. 1. The importance of serum protein binding in determining antimicrobial activity and concentration in serum.

Authors:  C M Kunin
Journal:  Clin Pharmacol Ther       Date:  1966 Mar-Apr       Impact factor: 6.875

6.  Studies on the relationship of protein binding and gel-affinity of antibiotics including penicillins.

Authors:  T Murakawa; Y Wakai; M Nishida
Journal:  J Antibiot (Tokyo)       Date:  1970-10       Impact factor: 2.649

Review 7.  Pharmacokinetics of the penicillins in man.

Authors:  M Barza; L Weinstein
Journal:  Clin Pharmacokinet       Date:  1976       Impact factor: 6.447

Review 8.  Clinical significance of protein binding of the penicillins.

Authors:  C M Kunin
Journal:  Ann N Y Acad Sci       Date:  1967-09-27       Impact factor: 5.691

9.  Binding of antibiotics to the human intracellular erythrocyte proteins hemoglobin and carbonic anhydase.

Authors:  M L Kornguth; C M Kunin
Journal:  J Infect Dis       Date:  1976-02       Impact factor: 5.226
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  4 in total

1.  Highly reproducible bactericidal activity test results by using a modified National Committee for Clinical Laboratory Standards broth macrodilution technique.

Authors:  D M Hacek; D C Dressel; L R Peterson
Journal:  J Clin Microbiol       Date:  1999-06       Impact factor: 5.948

Review 2.  Antibiotic tissue penetration and its relevance: impact of tissue penetration on infection response.

Authors:  D E Nix; S D Goodwin; C A Peloquin; D L Rotella; J J Schentag
Journal:  Antimicrob Agents Chemother       Date:  1991-10       Impact factor: 5.191

3.  Gentamicin intravenous infusion rate: effect on interstitial fluid concentration.

Authors:  A J Kozak; D N Gerding; L R Peterson; W H Hall
Journal:  Antimicrob Agents Chemother       Date:  1977-11       Impact factor: 5.191

4.  Comparison of azlocillin, ceftizoxime, cefoxitin, and amikacin alone and in combination against Pseudomonas aeruginosa in a neutropenic-site rabbit model.

Authors:  L R Peterson; D N Gerding; J A Moody; C E Fasching
Journal:  Antimicrob Agents Chemother       Date:  1984-05       Impact factor: 5.191
  4 in total

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