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Literature DB >> 879750

Exudate levels and bactericidal activity of cefazolin in a new local infection system using rat granuloma pouches.

Abstract

An experimental local infection system has been developed in which exudates are induced with croton oil in granuloma pouches of rats. This system provided a suitable model for the evaluation of the therapeutic effect of two antibiotics, cefazolin and cephalothin. Exudate levels of cefazolin were found to be higher than those of cephalothin, and these levels correlated with the higher serum level of cefazolin. The therapeutic effect of cefazolin, after intramuscular injection of 20 mg of each antibiotic per kg, was superior to that of cephalothin in eradicating both Staphylococcus aureus and Escherichia coli.

Entities: Chemical Disease Species

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Year: 1977 PMID： 879750 PMCID： PMC352126 DOI： 10.1128/AAC.11.6.1042

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

6 in total

1. EFFECT OF SERUM BINDING ON THE DISTRIBUTION OF PENICILLINS IN THE RABBIT.

Authors: C M KUNIN
Journal: J Lab Clin Med Date: 1965-03

2. Use of granuloma pouch technic in the study of antiphlogistic corticoids.

Authors: H SELYE
Journal: Proc Soc Exp Biol Med Date: 1953-02

3. Effect of schedule of administration on the therapeutic efficacy of penicillin; importance of the aggregate time penicillin remains at effectively bactericidal levels.

Authors: H EAGLE; R FLEISCHMAN; A D MUSSELMAN
Journal: Am J Med Date: 1950-09 Impact factor: 4.965

4. Studies on protein binding of cefazolin and other antibiotics.

Authors: T Shimizu
Journal: Jpn J Antibiot Date: 1974-06

5. Cefazolin, a new semisynthetic cephalosporin antibiotic. 3. Absorption, excretion and tissue distribution in parenteral administration.

Authors: M Nishida; T Matsubara; T Murakawa; Y Mine; Y Yokota; S Goto; S Kuwahara
Journal: J Antibiot (Tokyo) Date: 1970-04 Impact factor: 2.649

6. An experimental analysis of the curative action of penicillin in acute bacterial infections. III. The effect of suppuration upon the antibacterial action of the drug.

Authors: M R SMITH; W B WOOD
Journal: J Exp Med Date: 1956-04-01 Impact factor: 14.307

6 in total

11 in total

1. Effect of protein binding in serum on therapeutic efficacy of cephem antibiotics.

Authors: S Tawara; S Matsumoto; T Kamimura; S Goto
Journal: Antimicrob Agents Chemother Date: 1992-01 Impact factor: 5.191

2. Effect of protein binding on drug penetration into blister fluid.

Authors: W C Shyu; R Quintiliani; C H Nightingale; M N Dudley
Journal: Antimicrob Agents Chemother Date: 1988-01 Impact factor: 5.191

3. Distribution of cefpirome (HR 810) to exudate in the croton oil-induced rat granuloma pouch and its therapeutic effects on experimental infections in the pouch.

Authors: S Arai; S Kobayashi; S Hayashi; T Sakaguchi
Journal: Antimicrob Agents Chemother Date: 1988-09 Impact factor: 5.191

4. The granuloma pouch: an in vivo model for pharmacokinetic and chemotherapeutic investigations. I. Biochemical and histological characterization.

Authors: A Dalhoff; G Frank; G Luckhaus
Journal: Infection Date: 1982 Nov-Dec Impact factor: 3.553

Exudate levels and bactericidal activity of cefazolin in a new local infection system using rat granuloma pouches.

1. EFFECT OF SERUM BINDING ON THE DISTRIBUTION OF PENICILLINS IN THE RABBIT.

2. Use of granuloma pouch technic in the study of antiphlogistic corticoids.

3. Effect of schedule of administration on the therapeutic efficacy of penicillin; importance of the aggregate time penicillin remains at effectively bactericidal levels.

4. Studies on protein binding of cefazolin and other antibiotics.

5. Cefazolin, a new semisynthetic cephalosporin antibiotic. 3. Absorption, excretion and tissue distribution in parenteral administration.

6. An experimental analysis of the curative action of penicillin in acute bacterial infections. III. The effect of suppuration upon the antibacterial action of the drug.

1. Effect of protein binding in serum on therapeutic efficacy of cephem antibiotics.

2. Effect of protein binding on drug penetration into blister fluid.

3. Distribution of cefpirome (HR 810) to exudate in the croton oil-induced rat granuloma pouch and its therapeutic effects on experimental infections in the pouch.

4. The granuloma pouch: an in vivo model for pharmacokinetic and chemotherapeutic investigations. I. Biochemical and histological characterization.

5. Bactericidal activity of cephalosporins in an in vitro model simulating serum levels.

6. Cefazolin and cephradine: relationship between serum concentrations and tissue contents in mice.

7. Ascitic fluid cephalosporin concentrations: influence of protein binding and serum pharmacokinetics.

8. Static and dynamic properties of tissue cage fluid in rabbits.

9. Mouse model for evaluation of antibiotic treatment of acute and chronic infections.

10. Pharmacokinetics of fosmidomycin, a new phosphonic acid antibiotic.