Literature DB >> 8797239

Attention and regional cerebral blood flow in posttraumatic stress disorder patients with substance abuse histories.

W E Semple1, P F Goyer, R McCormick, B Compton-Toth, E Morris, B Donovan, G Muswick, D Nelson, M L Garnett, J Sharkoff, G Leisure, F Miraldi, S C Schulz.   

Abstract

Performance on an attentional task was assessed in posttraumatic stress disorder patients with substance abuse histories (PTSD-SA). Positron emission tomography (PET) was used to measure concurrent regional cerebral blood flow (rCBF). Eight male PTSD-SA patients and eight normal subjects each received three serial PET scans with 15O-labeled water under the following conditions: (1) resting, (2) auditory continuous performance task (ACPT1), and (3) repeat auditory task (ACPT2). PTSD-SA patients made more errors of commission on the ACPT than normal subjects. Examination of right frontal and parietal cortex ACPT task substrates revealed decreased parietal blood flow in PTSD-SA, which may represent a pathophysiology for poor attentional task performance in PTSD-SA. Attentional problems may underlie other symptomatology in PTSD.

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Year:  1996        PMID： 8797239     DOI： 10.1016/0925-4927(96)02735-7

Source DB:  PubMed          Journal:  Psychiatry Res        ISSN： 0165-1781            Impact factor:   3.222


  18 in total

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