| Literature DB >> 879713 |
Abstract
The likelihood of human pedigree data can be written in such a form as to allow the computation of derivatives. This is done for various parameters in linkage and segregation analysis. The equations for the maximum likelihood estimates are represented in a particularly appealing form which allows iterative solutions. This process is an extension to pedigress of Smith's (1957) counting methods. All these procedures belong to a general class of MLE methods for incomplete data called EM algorithms (Dempster et al. 1976).Entities:
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Year: 1977 PMID： 879713
Source DB: PubMed Journal: Ann Hum Genet ISSN： 0003-4800 Impact factor: 1.670