Literature DB >> 8796849

The p53 tumour suppressor gene: a model for molecular epidemiology of human cancer.

T Soussi1.   

Abstract

The gene encoding the tumour suppressor protein p53 is one of the most commonly mutated genes in human cancers. Analysis of the mutational events that target the p53 gene has revealed evidence for both exogenous and endogenous mutational mechanisms. For example, the p53 mutational spectrum reveals evidence for a direct causal effect of ultraviolet radiation in skin cancer, of aflatoxin B1 in liver cancer and of tobacco smoke in lung cancer. This novel field, molecular epidemiology of human cancer risk, has added a new dimension to classical associative epidemiology by providing a direct link between human cancer and carcinogen exposure.

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Year:  1996        PMID： 8796849     DOI： 10.1016/1357-4310(96)88756-9

Source DB:  PubMed          Journal:  Mol Med Today        ISSN： 1357-4310


  11 in total

1.  Protein kinase CK2 interacts with a multi-protein binding domain of p53.

Authors:  C Götz; P Scholtes; A Prowald; N Schuster; W Nastainczyk; M Montenarh
Journal:  Mol Cell Biochem       Date:  1999-01       Impact factor: 3.396

2.  Anti-p53 antibodies in patients with dermatomyositis/polymyositis.

Authors:  Yoshihiro Mimura; Norihito Yazawa; Zenshirou Tamaki; Ryuichi Ashida; Masatoshi Jinnin; Yoshihide Asano; Yayoi Tada; Masahide Kubo; Hironobu Ihn; Kunihiko Tamaki
Journal:  Clin Rheumatol       Date:  2006-11-21       Impact factor: 2.980

3.  Mutation and homozygous deletion analyses of genes that control the G1/S transition of the cell cycle in skin melanoma: p53, p21, p16 and p15.

Authors:  José Luis Soto Martínez; Carmen M Cabrera Morales; Sabio Serrano Ortega; Miguel Angel López-Nevot
Journal:  Clin Transl Oncol       Date:  2005-05       Impact factor: 3.405

4.  Mutations in the DNA-binding codons of TP53, which are associated with decreased expression of TRAILreceptor-2, predict for poor survival in diffuse large B-cell lymphoma.

Authors:  Ken H Young; Dennis D Weisenburger; Bhavana J Dave; Lynette Smith; Warren Sanger; Javeed Iqbal; Elias Campo; Jan Delabie; Randy D Gascoyne; German Ott; Lisa Rimsza; H Konrad Müller-Hermelink; Elaine S Jaffe; Andreas Rosenwald; Louis M Staudt; Wing C Chan; Timothy C Greiner
Journal:  Blood       Date:  2007-09-19       Impact factor: 22.113

5.  Apoptosis induced by nucleosides in the human hepatoma HepG2.

Authors:  Suh-Ching Yang; Che-Lin Chiu; Chi-Chang Huang; Jiun-Rong Chen
Journal:  World J Gastroenterol       Date:  2005-10-28       Impact factor: 5.742

6.  Database of p53 gene somatic mutations in human tumors and cell lines: updated compilation and future prospects.

Authors:  P Hainaut; T Soussi; B Shomer; M Hollstein; M Greenblatt; E Hovig; C C Harris; R Montesano
Journal:  Nucleic Acids Res       Date:  1997-01-01       Impact factor: 16.971

Review 7.  Genetic pathways and mutation profiles of human cancers: site- and exposure-specific patterns.

Authors:  I A Lea; M A Jackson; X Li; S Bailey; S D Peddada; J K Dunnick
Journal:  Carcinogenesis       Date:  2007-08-11       Impact factor: 4.944

8.  Structural profiles of TP53 gene mutations predict clinical outcome in diffuse large B-cell lymphoma: an international collaborative study.

Authors:  Ken H Young; Karen Leroy; Michael B Møller; Gisele W B Colleoni; Margarita Sánchez-Beato; Fábio R Kerbauy; Corinne Haioun; Jens C Eickhoff; Allen H Young; Philippe Gaulard; Miguel A Piris; Terry D Oberley; William M Rehrauer; Brad S Kahl; James S Malter; Elias Campo; Jan Delabie; Randy D Gascoyne; Andreas Rosenwald; Lisa Rimsza; James Huang; Rita M Braziel; Elaine S Jaffe; Wyndham H Wilson; Louis M Staudt; Julie M Vose; Wing C Chan; Dennis D Weisenburger; Timothy C Greiner
Journal:  Blood       Date:  2008-06-17       Impact factor: 22.113

Review 9.  Alterations of common chromosome fragile sites in hematopoietic malignancies.

Authors:  Hideshi Ishii; Yusuke Furukawa
Journal:  Int J Hematol       Date:  2004-04       Impact factor: 2.490

10.  Analysis of R213R and 13494 g-->a polymorphisms of the p53 gene in individuals with esophagitis, intestinal metaplasia of the cardia and Barrett's Esophagus compared with a control group.

Authors:  Diogo André Pilger; Patrícia Luciana da Costa Lopez; Fábio Segal; Sandra Leistner-Segal
Journal:  Genomic Med       Date:  2007-05-25
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