Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Acute poisoning with amphetamines (MDEA) and heroin: antagonistic effects between the two drugs.

Literature DB >> 8796401

Acute poisoning with amphetamines (MDEA) and heroin: antagonistic effects between the two drugs.

P G Jorens¹, L Heytens, H E Demey, S Andries, G A Ricaurte, L Bossaert, P J Schepens.

Abstract

A case of oral ingestion of large doses of both the amphetamine-derivative 3,4-methylene dioxyethamphetamine (MDEA) and heroin is reported. Despite high serum levels of both drugs, the patient did not present with the classic signs and symptoms normally seen during intoxication with these drugs. The patient recovered after symptomatic treatment. The possibility that opposite pharmacological properties of the two drugs prevented the patients death is discussed.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1996 PMID： 8796401 DOI： 10.1007/bf01712166

Source DB: PubMed Journal: Intensive Care Med ISSN： 0342-4642 Impact factor: 17.440

17 in total

Review 1. The 1988 Merck Frosst Award. The role of ascending and descending noradrenergic and serotonergic pathways in opioid and non-opioid antinociception as revealed by lesion studies.

Authors: J Sawynok
Journal: Can J Physiol Pharmacol Date: 1989-09 Impact factor: 2.273

Review 2. Regulatory proteins in presynaptic function.

Authors: G Hertting; S Wurster; C Allgaier
Journal: Ann N Y Acad Sci Date: 1990 Impact factor: 5.691

3. Neuroendocrine and mood responses to intravenous L-tryptophan in 3,4-methylenedioxymethamphetamine (MDMA) users. Preliminary observations.

Authors: L H Price; G A Ricaurte; J H Krystal; G R Heninger
Journal: Arch Gen Psychiatry Date: 1989-01

4. Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy")

Authors: J A Henry; K J Jeffreys; S Dawling
Journal: Lancet Date: 1992-08-15 Impact factor: 79.321

5. 'Eve' and 'Ecstasy'. A report of five deaths associated with the use of MDEA and MDMA.

Authors: G P Dowling; E T McDonough; R O Bost
Journal: JAMA Date: 1987-03-27 Impact factor: 56.272

6. The molecular mechanism of "ecstasy" [3,4-methylenedioxy-methamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release.

Authors: G Rudnick; S C Wall
Journal: Proc Natl Acad Sci U S A Date: 1992-03-01 Impact factor: 11.205

7. 5-HT2 antagonists stereoselectively prevent the neurotoxicity of 3,4-methylenedioxymethamphetamine by blocking the acute stimulation of dopamine synthesis: reversal by L-dopa.

Authors: C J Schmidt; V L Taylor; G M Abbate; T R Nieduzak
Journal: J Pharmacol Exp Ther Date: 1991-01 Impact factor: 4.030

Acute poisoning with amphetamines (MDEA) and heroin: antagonistic effects between the two drugs.

Review 1. The 1988 Merck Frosst Award. The role of ascending and descending noradrenergic and serotonergic pathways in opioid and non-opioid antinociception as revealed by lesion studies.

Review 2. Regulatory proteins in presynaptic function.

3. Neuroendocrine and mood responses to intravenous L-tryptophan in 3,4-methylenedioxymethamphetamine (MDMA) users. Preliminary observations.

4. Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy")

5. 'Eve' and 'Ecstasy'. A report of five deaths associated with the use of MDEA and MDMA.

6. The molecular mechanism of "ecstasy" [3,4-methylenedioxy-methamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release.

7. 5-HT2 antagonists stereoselectively prevent the neurotoxicity of 3,4-methylenedioxymethamphetamine by blocking the acute stimulation of dopamine synthesis: reversal by L-dopa.

8. Hallucinogenic amphetamine selectively destroys brain serotonin nerve terminals.

9. Behavioral effects of N-ethyl-3,4-methylenedioxyamphetamine (MDE; "EVE").

10. Ecstasy, 3-4 methylenedioxymethamphetamine (MDMA), a fatality associated with coagulopathy and hyperthermia.

1. On acute poisoning with amphetamines.