| Literature DB >> 8796285 |
D M Evans1, D M Jones, G R Pitt, D Ashworth, F De Clerck, F Verheyen, M Szelke.
Abstract
We have developed a series of novel, potent low molecular weight (4-600 Da) inhibitors of TK which were stable to cleavage by the enzyme and showed a high degree of selectivity for TK over several other serine proteases. Compound 7 (CH-2856) was found to reduce eosinophilia in a model of allergic inflammation. The effects observed in vivo provide further evidence for the involvement of TK and kinins in the pathophysiology of allergic diseases such as asthma.Entities:
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Year: 1996 PMID： 8796285 DOI： 10.1016/0162-3109(95)00069-0
Source DB: PubMed Journal: Immunopharmacology ISSN： 0162-3109