Literature DB >> 8796189

Modeling of heart excitation patterns caused by a local inhomogeneity.

R R Aliev1, A V Panfilov.   

Abstract

We simulate wave propagation in the whole heart containing a local inhomogeneity whose properties mimic some properties of cardiac tissue during the acute phase of infarction. The dynamics of cardiac tissue is described by a FitzHugh-Nagumo (FHN) model. We show that two or several short-period stimulations of the heart lead to the development of a three-dimensional vortex ring, which is a temporal source of high frequency waves. The vortex ring is located near the boundary of the infarction and induces wave patterns which appear as several focal wave sources on the epicard and endocard. We have traced the filament of the vortex and show its dynamics. Continuous stimulation of the heart at high frequency resulted in the Wenckebach effect.

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Year:  1996        PMID: 8796189     DOI: 10.1006/jtbi.1996.0112

Source DB:  PubMed          Journal:  J Theor Biol        ISSN: 0022-5193            Impact factor:   2.691


  6 in total

Review 1.  Electrophysiological modeling of cardiac ventricular function: from cell to organ.

Authors:  R L Winslow; D F Scollan; A Holmes; C K Yung; J Zhang; M S Jafri
Journal:  Annu Rev Biomed Eng       Date:  2000       Impact factor: 9.590

2.  Electrophysiology.

Authors:  Boyce E Griffith; Charles S Peskin
Journal:  Commun Pure Appl Math       Date:  2013-10-09       Impact factor: 2.774

Review 3.  Three-dimensional cardiac computational modelling: methods, features and applications.

Authors:  Alejandro Lopez-Perez; Rafael Sebastian; Jose M Ferrero
Journal:  Biomed Eng Online       Date:  2015-04-17       Impact factor: 2.819

Review 4.  A model model: a commentary on DiFrancesco and Noble (1985) 'A model of cardiac electrical activity incorporating ionic pumps and concentration changes'.

Authors:  Katharine Dibb; Andrew Trafford; Henggui Zhang; David Eisner
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2015-04-19       Impact factor: 6.237

5.  A Parsimonious Model of the Rabbit Action Potential Elucidates the Minimal Physiological Requirements for Alternans and Spiral Wave Breakup.

Authors:  Richard A Gray; Pras Pathmanathan
Journal:  PLoS Comput Biol       Date:  2016-10-17       Impact factor: 4.475

Review 6.  Patient-Specific Cardiovascular Computational Modeling: Diversity of Personalization and Challenges.

Authors:  Richard A Gray; Pras Pathmanathan
Journal:  J Cardiovasc Transl Res       Date:  2018-03-06       Impact factor: 4.132

  6 in total

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