PURPOSE: Contact versus noncontact transscleral neodymium:YAG laser cyclophotocoagulation was compared in a rabbit model with respect to the effects on intraocular pressure and pathologic findings. METHODS: Thirty-two rabbits received comparable energy levels (2 joules) of contact and noncontact cyclophotocoagulation. Pneumotonometry was performed every other day following treatment. RESULTS: For both the 2-week and 8-week periods following treatment, intraocular pressure was significantly lower in eyes receiving contact cyclophotocoagulation than in eyes receiving noncontact cyclophotocoagulation (for the 2-week period, mean difference in intraocular pressure was 5.3 mm Hg, n = 22, p < 0.001; for the 8-week period, mean difference in intraocular pressure was 4.3 mm Hg, n = 17, p < 0.013). Pathologic findings include acute ciliary body hemorrhage and inflammation (1 day), chronic inflammation (1 week), granulation tissue within laser lesions (2 weeks), and marked ciliary body atrophy (8 weeks). CONCLUSIONS: In our rabbit model, contact cyclophotocoagulation was more effective in lowering intraocular pressure than noncontact cyclophotocoagulation. Both contact and noncontact cyclophotocoagulation produced a variety of pathologic lesions in the rabbit eye, including cataract, phthisis bulbi, and anterior synechiae.
PURPOSE: Contact versus noncontact transscleral neodymium:YAG laser cyclophotocoagulation was compared in a rabbit model with respect to the effects on intraocular pressure and pathologic findings. METHODS: Thirty-two rabbits received comparable energy levels (2 joules) of contact and noncontact cyclophotocoagulation. Pneumotonometry was performed every other day following treatment. RESULTS: For both the 2-week and 8-week periods following treatment, intraocular pressure was significantly lower in eyes receiving contact cyclophotocoagulation than in eyes receiving noncontact cyclophotocoagulation (for the 2-week period, mean difference in intraocular pressure was 5.3 mm Hg, n = 22, p < 0.001; for the 8-week period, mean difference in intraocular pressure was 4.3 mm Hg, n = 17, p < 0.013). Pathologic findings include acute ciliary body hemorrhage and inflammation (1 day), chronic inflammation (1 week), granulation tissue within laser lesions (2 weeks), and marked ciliary body atrophy (8 weeks). CONCLUSIONS: In our rabbit model, contact cyclophotocoagulation was more effective in lowering intraocular pressure than noncontact cyclophotocoagulation. Both contact and noncontact cyclophotocoagulation produced a variety of pathologic lesions in the rabbit eye, including cataract, phthisis bulbi, and anterior synechiae.
Authors: Lars Wagenfeld; Hendrik Schwarzer; Gernot Roessler; Maren Klemm; Christos Skevas; Gisbert Richard; Oliver Zeitz Journal: Biomed Res Int Date: 2014-06-29 Impact factor: 3.411