J C Meurice1, I Marc, F Sériès. 1. Unité de Recherche, Centre de Pneumologie, Hôpital Laval, Université Laval, Sainte-Foy, Québec, Canada.
Abstract
BACKGROUND: To evaluate the possible influence of endorphin release on upper airway collapsibility the effects of naloxone, an opiate receptor antagonist, were measured. METHODS: The effects of naloxone on upper airway collapsibility were studied in five normal sleeping men in a pilot study. During a sleep fragmentation night the subjects received either naloxone or a volume matched saline placebo in a double blind crossover design. Critical pressure (Pcrit) was measured during a morning nap following sleep fragmentation. RESULTS: The plasma levels of endorphins increased during sleep fragmentation nights. Pcrit was significantly greater after placebo than after naloxone infusion. CONCLUSIONS:Naloxone may reduce upper airway collapsibility in normal sleeping subjects following sleep fragmentation.
RCT Entities:
BACKGROUND: To evaluate the possible influence of endorphin release on upper airway collapsibility the effects of naloxone, an opiate receptor antagonist, were measured. METHODS: The effects of naloxone on upper airway collapsibility were studied in five normal sleeping men in a pilot study. During a sleep fragmentation night the subjects received either naloxone or a volume matched saline placebo in a double blind crossover design. Critical pressure (Pcrit) was measured during a morning nap following sleep fragmentation. RESULTS: The plasma levels of endorphins increased during sleep fragmentation nights. Pcrit was significantly greater after placebo than after naloxone infusion. CONCLUSIONS:Naloxone may reduce upper airway collapsibility in normal sleeping subjects following sleep fragmentation.
Authors: Barry Krakow; Dominic Melendrez; Teddy D Warner; Richard Dorin; Ronald Harper; Michael Hollifield Journal: Sleep Breath Date: 2002-12 Impact factor: 2.816