Literature DB >> 8795570

No defect in G1/S cell cycle arrest in irradiated Li-Fraumeni lymphoblastoid cell lines.

K J Williams1, J Heighway, J M Birch, J D Norton, D Scott.   

Abstract

The radiation response of Epstein-Barr virus (EBV)-immortalised lymphoblastoid cell lines derive from Li-Fraumeni syndrome (LFS) and LFS-like individuals was investigated. Cells from all LFS and LFS-like cases showed an accumulation of p53 protein following 137Cs gamma-irradiation, which was associated with cell cycle arrest at the G1/S border. This response was indistinguishable from that seen in cells derived from normal individuals, and occurred in cases with missense mutations in the TP53 gene at codons 175, 180, 220 and 248 and also in two LFS-like individuals with no TP53 mutation. Previous studies using lymphocytes and fibroblasts from LFS individuals have demonstrated abnormal radiation responses in these cells. This suggest cell type specificity in the contribution of a mutant p53 protein to phenotype.

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Year:  1996        PMID： 8795570      PMCID： PMC2074690          DOI： 10.1038/bjc.1996.424

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  23 in total

1.  Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation.

Authors:  J Milner; E A Medcalf
Journal:  Cell       Date:  1991-05-31       Impact factor: 41.582

2.  Rhabdomyosarcoma in children: epidemiologic study and identification of a familial cancer syndrome.

Authors:  F P Li; J F Fraumeni
Journal:  J Natl Cancer Inst       Date:  1969-12       Impact factor: 13.506

3.  p53 germline mutations in Li-Fraumeni syndrome.

Authors:  M F Santibáñez-Koref; J M Birch; A L Hartley; P H Jones; A W Craft; T Eden; D Crowther; A M Kelsey; M Harris
Journal:  Lancet       Date:  1991-12-14       Impact factor: 79.321

4.  Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: aneuploidy and immortalization.

Authors:  F Z Bischoff; S O Yim; S Pathak; G Grant; M J Siciliano; B C Giovanella; L C Strong; M A Tainsky
Journal:  Cancer Res       Date:  1990-12-15       Impact factor: 12.701

5.  Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome.

Authors:  S Srivastava; Z Q Zou; K Pirollo; W Blattner; E H Chang
Journal:  Nature       Date:  1990 Dec 20-27       Impact factor: 49.962

6.  Transmission of in-vitro radioresistance in a cancer-prone family.

Authors:  N T Bech-Hansen; W A Blattner; B M Sell; E A McKeen; B C Lampkin; J F Fraumeni; M C Paterson
Journal:  Lancet       Date:  1981-06-20       Impact factor: 79.321

7.  Participation of p53 protein in the cellular response to DNA damage.

Authors:  M B Kastan; O Onyekwere; D Sidransky; B Vogelstein; R W Craig
Journal:  Cancer Res       Date:  1991-12-01       Impact factor: 12.701

8.  Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

Authors:  S J Kuerbitz; B S Plunkett; W V Walsh; M B Kastan
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-15       Impact factor: 11.205

9.  Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms.

Authors:  D Malkin; F P Li; L C Strong; J F Fraumeni; C E Nelson; D H Kim; J Kassel; M A Gryka; F Z Bischoff; M A Tainsky
Journal:  Science       Date:  1990-11-30       Impact factor: 47.728

10.  A possible screening test for inherited p53-related defects based on the apoptotic response of peripheral blood lymphocytes to DNA damage.

Authors:  R S Camplejohn; P Perry; S V Hodgson; G Turner; A Williams; C Upton; C MacGeoch; S Mohammed; D M Barnes
Journal:  Br J Cancer       Date:  1995-09       Impact factor: 7.640
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  3 in total

1.  The need for dynamic methods for measuring cell cycle perturbations: a study in radiation-treated lymphoblastoid cell lines of varying p53 status.

Authors:  R Gilchrist; M E Lomax; R S Camplejohn
Journal:  Cell Prolif       Date:  1999-02       Impact factor: 6.831

Review 2.  Li-Fraumeni syndrome--a molecular and clinical review.

Authors:  J M Varley; D G Evans; J M Birch
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640

3.  The relationship between radiation-induced G(1)arrest and chromosome aberrations in Li-Fraumeni fibroblasts with or without germline TP53 mutations.

Authors:  J M Boyle; A Spreadborough; M J Greaves; J M Birch; J M Varley; D Scott
Journal:  Br J Cancer       Date:  2001-07-20       Impact factor: 7.640
  3 in total

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