BACKGROUND: Current experience with carotid body tumors suggesting a high prevalence of associated cervical paragangliomas prompted this review. PATIENTS AND METHODS: An 8-year retrospective study of patients with carotid body tumors was undertaken, detailing presentation, diagnosis, and treatment. RESULTS: Eleven patients harboring 17 carotid body tumors were discovered. All patients had a neck mass. Seven patients (64%) had bilateral carotid body tumors. Six (55%) reported a positive family history-4 were first-generation relatives, 5 had bilateral tumors, and 3 had other head and neck paragangliomas. Angiography documented 4 associated vagal and 2 glomus jugulare paragangliomas in addition to the carotid body tumors. Precise surgical care limited blood loss to an average of 590 cc. The carotid artery was repaired during 5 resections (29%). Cranial nerve injury occurred in 3 cases, all following vagal body or glomus jugulare resection. Every patient is currently alive, stroke free, and functioning without major disability. CONCLUSIONS: Patients with carotid body tumors have a propensity for multiple head and neck paragangliomas. Angiography is diagnostic. The need for associated paraganglioma resection dramatically increases the risk of cranial nerve injury.
BACKGROUND: Current experience with carotid body tumors suggesting a high prevalence of associated cervical paragangliomas prompted this review. PATIENTS AND METHODS: An 8-year retrospective study of patients with carotid body tumors was undertaken, detailing presentation, diagnosis, and treatment. RESULTS: Eleven patients harboring 17 carotid body tumors were discovered. All patients had a neck mass. Seven patients (64%) had bilateral carotid body tumors. Six (55%) reported a positive family history-4 were first-generation relatives, 5 had bilateral tumors, and 3 had other head and neck paragangliomas. Angiography documented 4 associated vagal and 2 glomus jugulare paragangliomas in addition to the carotid body tumors. Precise surgical care limited blood loss to an average of 590 cc. The carotid artery was repaired during 5 resections (29%). Cranial nerve injury occurred in 3 cases, all following vagal body or glomus jugulare resection. Every patient is currently alive, stroke free, and functioning without major disability. CONCLUSIONS:Patients with carotid body tumors have a propensity for multiple head and neck paragangliomas. Angiography is diagnostic. The need for associated paraganglioma resection dramatically increases the risk of cranial nerve injury.
Authors: L T van Hulsteijn; N van Duinen; M K Ninaber; J A Romijn; J G van Dijk; K W van Kralingen; B Havekes; L Smid; G J Lammers; J C Jansen; J W Smit; R D Thijs; E P M Corssmit Journal: Sleep Breath Date: 2013-05-09 Impact factor: 2.816
Authors: H Dannenberg; R R de Krijger; J Zhao; E J Speel; P Saremaslani; W N Dinjens; W J Mooi; J Roth; P U Heitz; P Komminoth Journal: Am J Pathol Date: 2001-06 Impact factor: 4.307
Authors: Anna V Kudryavtseva; Elena N Lukyanova; Dmitry V Kalinin; Andrew R Zaretsky; Anatoly V Pokrovsky; Alexander L Golovyuk; Maria S Fedorova; Elena A Pudova; Sergey L Kharitonov; Vladislav S Pavlov; Anastasiya A Kobelyatskaya; Nataliya V Melnikova; Alexey A Dmitriev; Andrey P Polyakov; Boris Y Alekseev; Marina V Kiseleva; Andrey D Kaprin; George S Krasnov; Anastasiya V Snezhkina Journal: BMC Med Genomics Date: 2019-03-13 Impact factor: 3.063