Literature DB >> 8794843

Fibroblasts from Li-Fraumeni patients are resistant to low dose-rate irradiation.

A R Sproston1, J M Boyle, J Heighway, J M Birch, D Scott.   

Abstract

A group of adult skin fibroblast cultures from four individuals representing Li-Fraumeni families with different mutations in the p53 gene were found to be resistant to low dose-rate (0.011 Gy per min) 60Co radiation when compared with a control group of four cultures from normal individuals. The Li-Fraumeni fibroblasts, which could not be distinguished from controls after high dose rate (1.07 Gy per min) irradiation, were shown to be heterozygous (+/mut) at the p53 locus at the time of irradiation.

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Year:  1996        PMID： 8794843     DOI： 10.1080/095530096145139

Source DB:  PubMed          Journal:  Int J Radiat Biol        ISSN： 0955-3002            Impact factor:   2.694


  7 in total

1.  Inverse radiation dose-rate effects on somatic and germ-line mutations and DNA damage rates.

Authors:  M M Vilenchik; A G Knudson
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-09       Impact factor: 11.205

Review 2.  Malignant transformation and new primary tumours after therapeutic radiation for benign disease: substantial risks in certain tumour prone syndromes.

Authors:  D G R Evans; J M Birch; R T Ramsden; S Sharif; M E Baser
Journal:  J Med Genet       Date:  2005-09-09       Impact factor: 6.318

Review 3.  [Evaluation of cancer risk through genetic analysis?].

Authors:  A Luz
Journal:  Strahlenther Onkol       Date:  1997-09       Impact factor: 3.621

Review 4.  Li-Fraumeni syndrome--a molecular and clinical review.

Authors:  J M Varley; D G Evans; J M Birch
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640

5.  TP53 oncomorphic mutations predict resistance to platinum‑ and taxane‑based standard chemotherapy in patients diagnosed with advanced serous ovarian carcinoma.

Authors:  Pavla Brachova; Samuel R Mueting; Matthew J Carlson; Michael J Goodheart; Anna M Button; Sarah L Mott; Donghai Dai; Kristina W Thiel; Eric J Devor; Kimberly K Leslie
Journal:  Int J Oncol       Date:  2014-11-11       Impact factor: 5.650

6.  Oncomorphic TP53 Mutations in Gynecologic Cancers Lose the Normal Protein:Protein Interactions with the microRNA Microprocessing Complex.

Authors:  Pavla Brachova; Samuel R Mueting; Eric J Devor; Kimberly K Leslie
Journal:  J Cancer Ther       Date:  2014-06-01

7.  Chromosome instability is a predominant trait of fibroblasts from Li-Fraumeni families.

Authors:  J M Boyle; E L Mitchell; M J Greaves; S A Roberts; K Tricker; E Burt; J M Varley; J M Birch; D Scott
Journal:  Br J Cancer       Date:  1998-06       Impact factor: 7.640
  7 in total

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