Mechanisms of taste transduction.

Taste cells use a wide variety of mechanisms for transduction. Ionic stimuli, such as salts and acids, interact directly with ion channels to depolarize taste cells. More complex stimuli, such as sugars and amino acids, utilize apically located receptors for transduction. Recent molecular biological results suggest that the metabotropic glutamate receptor mGluR4 may function in glutamate taste transduction. New biochemical studies have identified a bitter-responsive receptor that activates gustducin. Unexpected results with knockout mice suggest that gustducin may be directly involved in both bitter and sweet transduction. Electrophysiological experiments indicate that both inositol trisphosphate and cyclic nucleotides function in both bitter and sweet transduction events.