Evaluation of the Grodins respiratory model via dynamic end-tidal forcing.

The Grodins model for respiratory physiology is very descriptive in simulating the lung-blood-tissue gas transport and exchange system, including detail not found in previous or more recent models. Three alternative controllers have been proposed for control of this gas exchange system. This paper indicates how dynamic endtidal forcing enhances behavioral differences among these three controllers and therefore enhances discrimination when the behavior is compared with subject data. Previously published end-tidal forcing data are used in the comparison. Several deficiencies in the controllers for the Grodins model are indicated.