M Makrides1, M A Neumann, R A Gibson. 1. Department of Paediatrics & Child Health, Flinders Medical Centre, Bedford Park, Adelaide, SA, Australia.
Abstract
OBJECTIVE: To assess the effect of varying maternal intake of docosahexaenoic acid (DHA, 22 : 6n-3), in the absence of other dietary polyunsaturates, on breast milk fatty acids. DESIGN AND INTERVENTION: Lactating mothers were randomised on day 5 post-partum to groups consuming equal numbers of capsules but containing either placebo or an oil containing DHA (43%) as its only polyunsaturate to receive 0, 0.2, 0.4, 0.9, 1.3 g DHA/day. Breast milk fatty acids as well as maternal plasma and erythrocyte phospholipids were assessed at 12 weeks post partum by capillary gas chromatography. RESULTS:Breast milk DHA levels ranged from 0.2 to 1.7% of total fatty acids and increased in a dose dependent manner (r2 = 0.89, P < 0.01). Maternal plasma (r2 = 0.71, P < 0.01) and erythrocyte (r2 = 0.77, P < 0.01) phospholipid DHA levels increased and were also strongly associated with dietary dose of DHA. Increasing maternal dietary doses of DHA did not affect breast milk arachidonic acid (AA, 20 : 4n-6) levels or antioxidant status as measured by plasma vitamin A or E levels. CONCLUSIONS: Our results have demonstrated that DHA in the diet has a strong, specific and dose-dependent effect on breast milk DHA.
RCT Entities:
OBJECTIVE: To assess the effect of varying maternal intake of docosahexaenoic acid (DHA, 22 : 6n-3), in the absence of other dietary polyunsaturates, on breast milk fatty acids. DESIGN AND INTERVENTION: Lactating mothers were randomised on day 5 post-partum to groups consuming equal numbers of capsules but containing either placebo or an oil containing DHA (43%) as its only polyunsaturate to receive 0, 0.2, 0.4, 0.9, 1.3 g DHA/day. Breast milk fatty acids as well as maternal plasma and erythrocyte phospholipids were assessed at 12 weeks post partum by capillary gas chromatography. RESULTS: Breast milk DHA levels ranged from 0.2 to 1.7% of total fatty acids and increased in a dose dependent manner (r2 = 0.89, P < 0.01). Maternal plasma (r2 = 0.71, P < 0.01) and erythrocyte (r2 = 0.77, P < 0.01) phospholipidDHA levels increased and were also strongly associated with dietary dose of DHA. Increasing maternal dietary doses of DHA did not affect breast milk arachidonic acid (AA, 20 : 4n-6) levels or antioxidant status as measured by plasma vitamin A or E levels. CONCLUSIONS: Our results have demonstrated that DHA in the diet has a strong, specific and dose-dependent effect on breast milk DHA.
Authors: Melanie A Martin; William D Lassek; Steven J C Gaulin; Rhobert W Evans; Jessica G Woo; Sheela R Geraghty; Barbara S Davidson; Ardythe L Morrow; Hillard S Kaplan; Michael D Gurven Journal: Matern Child Nutr Date: 2012-05-24 Impact factor: 3.092
Authors: Christina J Valentine; Kelly A Dingess; Jeanne Kleiman; Ardythe L Morrow; Lynette K Rogers Journal: J Pediatr Gastroenterol Nutr Date: 2019-09 Impact factor: 2.839
Authors: Linda M Arterburn; Harry A Oken; James P Hoffman; Eileen Bailey-Hall; Gloria Chung; Dror Rom; Jacqueline Hamersley; Deanna McCarthy Journal: Lipids Date: 2007-08-23 Impact factor: 1.880
Authors: Renate L Bergmann; Elisabeth Haschke-Becher; Petra Klassen-Wigger; Karl E Bergmann; Rolf Richter; Joachim W Dudenhausen; Dominik Grathwohl; Ferdinand Haschke Journal: Ann Nutr Metab Date: 2008-04-29 Impact factor: 3.374