Literature DB >> 8793292

Disease mechanism: unravelling Wiskott-Aldrich syndrome.

T Kirchhausen1, F S Rosen.   

Abstract

The gene responsible for Wiskott-Aldrich syndrome, a disease affecting platelets and lymphocytes, has been cloned and its protein product (WASp) found to interact with the GTPase Cdc42. WASp seems to provide a link between Cdc42 and the actin cytoskeleton, perhaps explaining the cellular defects underlying the disease.

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Year:  1996        PMID： 8793292     DOI： 10.1016/s0960-9822(09)00447-3

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


  11 in total

Review 1.  Small GTPases in lymphocyte biology: Rho proteins take center stage.

Authors:  S Henning; S Cleverley
Journal:  Immunol Res       Date:  1999       Impact factor: 2.829

Review 2.  Rho GTPases and their effector proteins.

Authors:  A L Bishop; A Hall
Journal:  Biochem J       Date:  2000-06-01       Impact factor: 3.857

Review 3.  Multifaceted role of Rho proteins in angiogenesis.

Authors:  Sofia D Merajver; Saad Z Usmani
Journal:  J Mammary Gland Biol Neoplasia       Date:  2005-10       Impact factor: 2.673

4.  Evolution of the eukaryotic ARP2/3 activators of the WASP family: WASP, WAVE, WASH, and WHAMM, and the proposed new family members WAWH and WAML.

Authors:  Martin Kollmar; Dawid Lbik; Stefanie Enge
Journal:  BMC Res Notes       Date:  2012-02-08

Review 5.  The Diverse Family of Arp2/3 Complexes.

Authors:  Javier Pizarro-Cerdá; Dror Shlomo Chorev; Benjamin Geiger; Pascale Cossart
Journal:  Trends Cell Biol       Date:  2016-08-29       Impact factor: 20.808

Review 6.  Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity.

Authors:  D I Johnson
Journal:  Microbiol Mol Biol Rev       Date:  1999-03       Impact factor: 11.056

7.  A novel mutation in Wiskott-Aldrich gene manifesting as macrothrombocytopenia and neutropenia.

Authors:  Mais Arwani; Daniel Lee; Abdullah Haddad; Prerna Mewawalla
Journal:  BMJ Case Rep       Date:  2018-07-10

8.  SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development.

Authors:  J E Bear; J F Rawls; C L Saxe
Journal:  J Cell Biol       Date:  1998-09-07       Impact factor: 10.539

9.  In vitro reconstitution of cortical actin assembly sites in budding yeast.

Authors:  T Lechler; R Li
Journal:  J Cell Biol       Date:  1997-07-14       Impact factor: 10.539

10.  Bee1, a yeast protein with homology to Wiscott-Aldrich syndrome protein, is critical for the assembly of cortical actin cytoskeleton.

Authors:  R Li
Journal:  J Cell Biol       Date:  1997-02-10       Impact factor: 10.539
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