R J Leo1, J L Kreeger, K Y Kim. 1. Department of Psychiatry, School of Medicine and Biomedical Sciences, State University of New York (SUNY) at Buffalo 14215, USA.
Abstract
OBJECTIVE: To report a case of symptomatic cardiomyopathy induced during treatment with clozapine, an antipsychotic of the dibenzodiazepine class. CASE SUMMARY: A patient with a long psychiatric history significant for schizophrenia and no prior cardiac history developed dyspnea, malaise, and edema with a low ventricular ejection fraction during clozapine therapy. DISCUSSION: The literature concerning cardiorespiratory complications with clozapine therapy is reviewed. CONCLUSIONS: Cardiorespiratory complications associated with clozapine use are rare. Caution may be warranted in patients treated with other medications, such as benzodiazepines, and in patients with underlying cardiac disease.
OBJECTIVE: To report a case of symptomatic cardiomyopathy induced during treatment with clozapine, an antipsychotic of the dibenzodiazepine class. CASE SUMMARY: A patient with a long psychiatric history significant for schizophrenia and no prior cardiac history developed dyspnea, malaise, and edema with a low ventricular ejection fraction during clozapine therapy. DISCUSSION: The literature concerning cardiorespiratory complications with clozapine therapy is reviewed. CONCLUSIONS: Cardiorespiratory complications associated with clozapine use are rare. Caution may be warranted in patients treated with other medications, such as benzodiazepines, and in patients with underlying cardiac disease.
Authors: Steven J Haas; Richard Hill; Henry Krum; Danny Liew; Andrew Tonkin; Lisa Demos; Karen Stephan; John McNeil Journal: Drug Saf Date: 2007 Impact factor: 5.606