L I Eriksson1. 1. Department of Anaesthesiology and Intensive Care, Karolinska Hospital and Institute, Stockholm, Sweden.
Abstract
BACKGROUND: It was hypothesized that non-depolarizing neuromuscular blocking agents impair hypoxic chemosensitivity in man. METHODS: In thirty randomly allocated male volunteers the hypoxic and hypercarbic ventilatory responses were measured during partial paralysis (TOF ratio 0.70) due to either atracurium (n = 10), pancuronium (n = 10) or vecuronium (n = 10). RESULTS:Hypoxic ventilatory responses were depressed by 306, 287 and 296% (mean SD) at steady-state infusion of atracurium, pancuronium and vecuronium, respectively. At a TOF ratio of > 0.90, the HVR was not different from control measurements. CONCLUSION: It is concluded that non-depolarizing neuromuscular blocking agents impair hypoxic ventilatory regulation. Further experimental studies are warranted to fully describe the mechanism(s) responsible for this interaction.
RCT Entities:
BACKGROUND: It was hypothesized that non-depolarizing neuromuscular blocking agents impair hypoxic chemosensitivity in man. METHODS: In thirty randomly allocated male volunteers the hypoxic and hypercarbic ventilatory responses were measured during partial paralysis (TOF ratio 0.70) due to either atracurium (n = 10), pancuronium (n = 10) or vecuronium (n = 10). RESULTS:Hypoxic ventilatory responses were depressed by 306, 287 and 296% (mean SD) at steady-state infusion of atracurium, pancuronium and vecuronium, respectively. At a TOF ratio of > 0.90, the HVR was not different from control measurements. CONCLUSION: It is concluded that non-depolarizing neuromuscular blocking agents impair hypoxic ventilatory regulation. Further experimental studies are warranted to fully describe the mechanism(s) responsible for this interaction.
Authors: Edoardo De Robertis; Geremia Zito Marinosci; Giovanni Marco Romano; Ornella Piazza; Michele Iannuzzi; Fabrizio Cirillo; Stefania De Simone; Giuseppe Servillo Journal: Clinicoecon Outcomes Res Date: 2016-06-29