Literature DB >> 8792678

Active constituents against HIV-1 protease from Garcinia mangostana.

S X Chen, M Wan, B N Loh.   

Abstract

The ethanol extract of Garcinia mangostana L. (Guttiferae) showed potent inhibitory activity against HIV-1 protease. The activity-guided purification of the extract resulted in the isolation of two active, known compounds. The chemical structures of the isolated compounds were established by spectroscopic analyses as mangostin (IC50 = 5.12 +/- 0.41 microM) and gamma-mangostin (IC50 = 4.81 +/- 0.32 microM). The type of inhibition by both compounds is noncompetitive.

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Year:  1996        PMID： 8792678     DOI： 10.1055/s-2006-957916

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.007


  15 in total

1.  A Method of Effectively Improved α-Mangostin Bioavailability.

Authors:  Yan Zhao; Guosheng Tang; Qiang Tang; Jing Zhang; Yingying Hou; Enbo Cai; Shuangli Liu; Daihong Lei; Lianxue Zhang; Shijie Wang
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2015-05-20       Impact factor: 2.441

2.  In vivo toxicity and antitumor activity of mangosteen extract.

Authors:  Nuttavut Kosem; Kazuhiro Ichikawa; Hideo Utsumi; Primchanien Moongkarndi
Journal:  J Nat Med       Date:  2012-05-24       Impact factor: 2.343

3.  Structural Characterization, Biological Effects, and Synthetic Studies on Xanthones from Mangosteen (Garcinia mangostana), a Popular Botanical Dietary Supplement.

Authors:  Young-Won Chin; A Douglas Kinghorn
Journal:  Mini Rev Org Chem       Date:  2008-11-01       Impact factor: 2.495

4.  Targeting Metabolic Reprogramming by Influenza Infection for Therapeutic Intervention.

Authors:  Heather S Smallwood; Susu Duan; Marie Morfouace; Svetlana Rezinciuc; Barry L Shulkin; Anang Shelat; Erika E Zink; Sandra Milasta; Resha Bajracharya; Ajayi J Oluwaseum; Martine F Roussel; Douglas R Green; Ljiljana Pasa-Tolic; Paul G Thomas
Journal:  Cell Rep       Date:  2017-05-23       Impact factor: 9.423

5.  Virtual screening of Indonesian herbal database as HIV-1 reverse transcriptase inhibitor.

Authors:  Rezi Riadhi Syahdi; Abdul Mun'im; Heru Suhartanto; Arry Yanuar
Journal:  Bioinformation       Date:  2012-12-08

6.  In vitro and in vivo anti-colon cancer effects of Garcinia mangostana xanthones extract.

Authors:  Abdalrahim F A Aisha; Khalid M Abu-Salah; Zhari Ismail; Amin Malik Shah Abdul Majid
Journal:  BMC Complement Altern Med       Date:  2012-07-20       Impact factor: 4.782

7.  Mangosteen xanthones suppress hepatitis C virus genome replication.

Authors:  Moonju Choi; Young-Mi Kim; Sungjin Lee; Young-Won Chin; Choongho Lee
Journal:  Virus Genes       Date:  2014-07-02       Impact factor: 2.198

8.  Hypoglycaemic activity of ethanolic extract of Garcinia mangostana Linn. in normoglycaemic and streptozotocin-induced diabetic rats.

Authors:  Muhammad Taher; Tg Muhamad Faris Syafiq Tg Zakaria; Deny Susanti; Zainul Amiruddin Zakaria
Journal:  BMC Complement Altern Med       Date:  2016-05-21       Impact factor: 3.659

Review 9.  Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus.

Authors:  Bahare Salehi; Nanjangud V Anil Kumar; Bilge Şener; Mehdi Sharifi-Rad; Mehtap Kılıç; Gail B Mahady; Sanja Vlaisavljevic; Marcello Iriti; Farzad Kobarfard; William N Setzer; Seyed Abdulmajid Ayatollahi; Athar Ata; Javad Sharifi-Rad
Journal:  Int J Mol Sci       Date:  2018-05-14       Impact factor: 5.923

10.  Apoptotic effects of γ-mangostin from the fruit hull of Garcinia mangostana on human malignant glioma cells.

Authors:  Hui-Fang Chang; Wen-Tsung Huang; Hui-Ju Chen; Ling-Ling Yang
Journal:  Molecules       Date:  2010-12-07       Impact factor: 4.927
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