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Literature DB >> 8792629

Two new naphthoquinones with antiviral activity from Rhinacanthus nasutus.

A Sendl¹, J L Chen, S D Jolad, C Stoddart, E Rozhon, M Kernan, W Nanakorn, M Balick.

Abstract

Two new naphthoquinones, rhinacanthin-C (1) and rhinacanthin-D (2), exhibit inhibitory activity against cytomegalovirus (CMV), with EC50 values of 0.02 and 0.22 microgram/mL, respectively, against human CMV. They were isolated from the medicinal plant Rhinacanthus nasutus (Acanthaceae). The structures of the compounds were determined by analysis of their spectroscopic data, in particular, 2D NMR.

Entities: Chemical Species

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Year: 1996 PMID： 8792629 DOI： 10.1021/np9601871

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

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Cited

11 in total

1. Synergy between rhinacanthins from Rhinacanthus nasutus in inhibition against mosquito cytochrome P450 enzymes.

Authors: Rattanawadee Kotewong; Phisit Pouyfung; Panida Duangkaew; Aruna Prasopthum; Pornpimol Rongnoparut
Journal: Parasitol Res Date: 2015-04-15 Impact factor: 2.289

2. Palladium-catalyzed enantioselective Heck alkenylation of acyclic alkenols using a redox-relay strategy.

Authors: Harshkumar H Patel; Matthew S Sigman
Journal: J Am Chem Soc Date: 2015-03-09 Impact factor: 15.419

3. Rhinacanthin C Inhibits Osteoclast Differentiation and Bone Resorption: Roles of TRAF6/TAK1/MAPKs/NF-κB/NFATc1 Signaling.

Authors: Mineko Tomomura; Ryuichiro Suzuki; Yoshiaki Shirataki; Hiroshi Sakagami; Nobuaki Tamura; Akito Tomomura
Journal: PLoS One Date: 2015-06-17 Impact factor: 3.240

4. Rhinacanthin C Alleviates Amyloid-β Fibrils' Toxicity on Neurons and Attenuates Neuroinflammation Triggered by LPS, Amyloid-β, and Interferon-γ in Glial Cells.

Authors: Kai-An Chuang; Ming-Han Li; Ni-Hsuan Lin; Chih-Hsuan Chang; I-Huang Lu; I-Hong Pan; Tomoya Takahashi; Ming-Der Perng; Shu-Fang Wen
Journal: Oxid Med Cell Longev Date: 2017-10-18 Impact factor: 6.543

10. Superoxide Scavenging and Antiglycation Activity of Rhinacanthins-rich Extract Obtained from the Leaves of Rhinacanthus nasutus.

Authors: Muhammad Ajmal Shah; Haji Muhammad; Yasir Mehmood; Ruqaiya Khalil; Zaheer Ul-Haq; Pharkphoom Panichayupakaranant
Journal: Pharmacogn Mag Date: 2017-11-13 Impact factor: 1.085

Two new naphthoquinones with antiviral activity from Rhinacanthus nasutus.

1. Synergy between rhinacanthins from Rhinacanthus nasutus in inhibition against mosquito cytochrome P450 enzymes.

2. Palladium-catalyzed enantioselective Heck alkenylation of acyclic alkenols using a redox-relay strategy.

3. Rhinacanthin C Inhibits Osteoclast Differentiation and Bone Resorption: Roles of TRAF6/TAK1/MAPKs/NF-κB/NFATc1 Signaling.

4. Rhinacanthin C Alleviates Amyloid-β Fibrils' Toxicity on Neurons and Attenuates Neuroinflammation Triggered by LPS, Amyloid-β, and Interferon-γ in Glial Cells.

5. Rhinacanthins-rich Extract Enhances Glucose Uptake and Inhibits Adipogenesis in 3T3-L1 Adipocytes and L6 Myotubes.

6. In-silico screening for anti-Zika virus phytochemicals.

7. Rhinacanthus nasutus protects cultured neuronal cells against hypoxia induced cell death.

Review 8. Emerging paradigms of viral diseases and paramount role of natural resources as antiviral agents.

9. Rhinacanthus nasutus Ameliorates Cytosolic and Mitochondrial Enzyme Levels in Streptozotocin-Induced Diabetic Rats.

10. Superoxide Scavenging and Antiglycation Activity of Rhinacanthins-rich Extract Obtained from the Leaves of Rhinacanthus nasutus.