| Literature DB >> 8792475 |
P J Johansson1, T Sveger, K Ahlfors, J Ekstrand, L Svensson.
Abstract
A previously healthy 3-month-old girl presented with symptoms of meningitis, diarrhoea, vomiting and fever. Green monkey kidney (GMK) cells inoculated with cerebrospinal fluid (CSF) revealed reovirus-like particles by electron microscopy. RNA-gel electrophoresis, immunofluorescence and virus neutralization identified the pathogen isolated from CSF as reovirus type 1. Antibody determination by immunofluorescence of paired sera showed a significant antibody titre rise to the CSF isolate and neutralization test revealed a greater than 4-fold antibody titre rise to the CSF isolate. The CSF isolate was also neutralized by reovirus type 1 antibodies. This report represents one of a few associating reovirus with CNS symptoms in humans.Entities:
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Year: 1996 PMID: 8792475 DOI: 10.3109/00365549609049060
Source DB: PubMed Journal: Scand J Infect Dis ISSN: 0036-5548