Literature DB >> 8791810

Isolated perfused liver.

K L Brouwer1, R G Thurman.   

Abstract

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Year:  1996        PMID： 8791810     DOI： 10.1007/978-1-4899-1863-5_10

Source DB:  PubMed          Journal:  Pharm Biotechnol        ISSN： 1078-0467


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  7 in total

1.  Altered Hepatobiliary Disposition of Tolvaptan and Selected Tolvaptan Metabolites in a Rodent Model of Polycystic Kidney Disease.

Authors:  James J Beaudoin; Jacqueline Bezençon; Yanguang Cao; Katsuhiko Mizuno; Sharin E Roth; William J Brock; Kim L R Brouwer
Journal:  Drug Metab Dispos       Date:  2018-11-30       Impact factor: 3.922

2.  Determination of intracellular unbound concentrations and subcellular localization of drugs in rat sandwich-cultured hepatocytes compared with liver tissue.

Authors:  Nathan D Pfeifer; Kevin B Harris; Grace Zhixia Yan; Kim L R Brouwer
Journal:  Drug Metab Dispos       Date:  2013-08-29       Impact factor: 3.922

3.  Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system.

Authors:  Liang Ma; Jeremy Barker; Changchun Zhou; Wei Li; Jing Zhang; Biaoyang Lin; Gregory Foltz; Jenni Küblbeck; Paavo Honkakoski
Journal:  Biomaterials       Date:  2012-03-18       Impact factor: 12.479

4.  Mechanisms underlying differences in systemic exposure of structurally similar active metabolites: comparison of two preclinical hepatic models.

Authors:  Grace Zhixia Yan; Kim L R Brouwer; Gary M Pollack; Michael Zhuo Wang; Richard R Tidwell; James E Hall; Mary F Paine
Journal:  J Pharmacol Exp Ther       Date:  2011-02-14       Impact factor: 4.030

5.  Hepatic metabolism and biliary excretion of silymarin flavonolignans in isolated perfused rat livers: role of multidrug resistance-associated protein 2 (Abcc2).

Authors:  Sonia R Miranda; Jin Kyung Lee; Kim L R Brouwer; Zhiming Wen; Philip C Smith; Roy L Hawke
Journal:  Drug Metab Dispos       Date:  2008-08-07       Impact factor: 3.922

6.  Modulation of trabectedin (ET-743) hepatobiliary disposition by multidrug resistance-associated proteins (Mrps) may prevent hepatotoxicity.

Authors:  Jin Kyung Lee; Elaine M Leslie; Maciej J Zamek-Gliszczynski; Kim L R Brouwer
Journal:  Toxicol Appl Pharmacol       Date:  2007-12-03       Impact factor: 4.219

7.  Hepatic basolateral efflux contributes significantly to rosuvastatin disposition II: characterization of hepatic elimination by basolateral, biliary, and metabolic clearance pathways in rat isolated perfused liver.

Authors:  Nathan D Pfeifer; Arlene S Bridges; Brian C Ferslew; Rhiannon N Hardwick; Kim L R Brouwer
Journal:  J Pharmacol Exp Ther       Date:  2013-09-30       Impact factor: 4.030
  7 in total

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